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Cardiovasc Ther. 2021 Dec 21;2021:7956161. doi: 10.1155/2021/7956161. eCollection 2021.

Serum PCSK9 Correlates with PTX3 and Apolipoproteins B, A1, and C3 Concentrations in Patients with Type 2 Diabetes.

Cardiovascular therapeutics

Małgorzata Waluś-Miarka, Maria Kapusta, Przemysław Miarka, Ewa Kawalec, Barbara Idzior-Waluś

Affiliations

  1. Department of Metabolic Diseases, Jagiellonian University Medical College, Jakubowskiego 2, 30-688 Krakow, Poland.
  2. University Hospital, Krakow, Poland.
  3. Department of Biochemistry, Jagiellonian University, Medical College, Poland.
  4. Department of Nephrology, Jagiellonian University Medical College, Poland.

PMID: 35024053 PMCID: PMC8714359 DOI: 10.1155/2021/7956161

Abstract

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is involved in the regulation of LDL metabolism. There is evidence that circulating PCSK9 is a cardiovascular risk factor. In this study, we determined factors associated with circulating PCSK9 in a group of patients with type 2 diabetes mellitus (DM2). Material included 116 consecutive patients with DM2 from outpatient diabetes clinic. Circulating PCSK9, PTX3, apolipoprotein (apo) B100, apo B48, and apo C3 levels were determined by ELISA, apo A1 by immunoturbidimetry. The mean (sd) age of patients was 59.1 (11.1) years, the mean (sd) values of serum PCSK9 were 255.4 (106.97) ng/ml. Circulating PCSK9 correlated negatively with age (

Copyright © 2021 Małgorzata Waluś-Miarka et al.

Conflict of interest statement

All authors declare no conflict of interest.

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