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Airiau K, Vacher P, Micheau O, et al. TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex. Cells. 2021;11(1)doi: 10.3390/cells11010057.
Airiau, K., Vacher, P., Micheau, O., Prouzet-Mauleon, V., Kroemer, G., Moosavi, M. A., & Djavaheri-Mergny, M. (2021). TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex. Cells, 11(1), . https://doi.org/10.3390/cells11010057
Airiau, Kelly, et al. "TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex." Cells vol. 11,1 (2021). doi: https://doi.org/10.3390/cells11010057
Airiau K, Vacher P, Micheau O, Prouzet-Mauleon V, Kroemer G, Moosavi MA, Djavaheri-Mergny M. TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex. Cells. 2021 Dec 25;11(1). doi: 10.3390/cells11010057. PMID: 35011619; PMCID: PMC8750441.
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Cells. 2021 Dec 25;11(1). doi: 10.3390/cells11010057.

TRAIL Triggers CRAC-Dependent Calcium Influx and Apoptosis through the Recruitment of Autophagy Proteins to Death-Inducing Signaling Complex.

Cells

Kelly Airiau, Pierre Vacher, Olivier Micheau, Valerie Prouzet-Mauleon, Guido Kroemer, Mohammad Amin Moosavi, Mojgan Djavaheri-Mergny

Affiliations

  1. Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
  2. Lipides, Nutrition Cancer, INSERM, UMR1231, 21079 Dijon, France.
  3. UFR Science de Santé, Université de Bourgogne, Franche-Comté, 21079 Dijon, France.
  4. Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Equipe 11 Labellisée par la Ligue Contre le Cancer, 75006 Paris, France.
  5. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.
  6. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France.
  7. Department of Molecular Medicine, National Institute of Genetic Engineering and Biotechnology, Tehran P.O. Box 14965/161, Iran.

PMID: 35011619 PMCID: PMC8750441 DOI: 10.3390/cells11010057

Abstract

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively kills various cancer cell types, but also leads to the activation of signaling pathways that favor resistance to cell death. Here, we investigated the as yet unknown roles of calcium signaling and autophagy regulatory proteins during TRAIL-induced cell death in leukemia cells. Taking advantage of the Gene Expression Profiling Interactive Analysis (GEPIA) project, we first found that leukemia patients present a unique TRAIL receptor gene expression pattern that may reflect their resistance to TRAIL. The exposure of NB4 acute promyelocytic leukemia cells to TRAIL induces intracellular Ca

Keywords: ATG7; ATRA; CRAC channels; DISC; ORAI1; autophagy; cancer; leukemia; p62/SQSTM1; resistance to therapy

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