Display options
Cite
Sun X, Siri S, Hurst A, et al. Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials. Cells. 2021;11(1)doi: 10.3390/cells11010114.
Sun, X., Siri, S., Hurst, A., & Qiu, H. (2021). Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials. Cells, 11(1), . https://doi.org/10.3390/cells11010114
Sun, Xiaonan, et al. "Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials." Cells vol. 11,1 (2021). doi: https://doi.org/10.3390/cells11010114
Sun X, Siri S, Hurst A, Qiu H. Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials. Cells. 2021 Dec 30;11(1). doi: 10.3390/cells11010114. PMID: 35011676; PMCID: PMC8750610.
Copy Download .nbib Format: NLM
Share it on

Cells. 2021 Dec 30;11(1). doi: 10.3390/cells11010114.

Heat Shock Protein 22 in Physiological and Pathological Hearts: Small Molecule, Large Potentials.

Cells

Xiaonan Sun, Sharadhi Siri, Amirah Hurst, Hongyu Qiu

Affiliations

  1. Center for Molecular and Translational Medicine, Institute of Biomedical Science, Georgia State University, Atlanta, GA 30303, USA.

PMID: 35011676 PMCID: PMC8750610 DOI: 10.3390/cells11010114

Abstract

Small heat shock protein 22 (HSP22) belongs to the superfamily of heat shock proteins and is predominantly expressed in the heart, brain, skeletal muscle, and different types of cancers. It has been found that HSP22 is involved in variant cellular functions in cardiomyocytes and plays a vital role in cardiac protection against cardiomyocyte injury under diverse stress. This review summarizes the multiple functions of HSP22 in the heart and the underlying molecular mechanisms through modulating gene transcription, post-translational modification, subcellular translocation of its interacting proteins, and protein degradation, facilitating mitochondrial function, cardiac metabolism, autophagy, and ROS production and antiapoptotic effect. We also discuss the association of HSP22 in cardiac pathologies, including human dilated cardiomyopathy, pressure overload-induced heart failure, ischemic heart diseases, and aging-related cardiac metabolism disorder. The collected information would provide insights into the understanding of the HSP22 in heart diseases and lead to discovering the therapeutic targets.

Keywords: HSP22; aging; cardiac hypertrophy; cardiomyopathy; heart; myocardial ischemia

References

  1. Cells. 2019 Dec 24;9(1): - PubMed
  2. PLoS One. 2013 May 21;8(5):e63886 - PubMed
  3. Biochem J. 2004 Jul 15;381(Pt 2):379-87 - PubMed
  4. Antioxidants (Basel). 2021 Sep 29;10(10): - PubMed
  5. Cardiovasc Res. 2014 Jun 1;102(3):346-61 - PubMed
  6. Cardiovasc Res. 2008 Feb 1;77(3):497-505 - PubMed
  7. Arch Biochem Biophys. 2015 Apr 1;571:40-9 - PubMed
  8. Drug Des Devel Ther. 2019 Jul 30;13:2619-2632 - PubMed
  9. J Clin Invest. 2017 Aug 1;127(8):3189-3200 - PubMed
  10. Circ Res. 2006 Feb 3;98(2):280-8 - PubMed
  11. Circ Res. 2009 Apr 10;104(7):887-95 - PubMed
  12. J Am Heart Assoc. 2019 Jun 18;8(12):e012673 - PubMed
  13. Curr Biol. 2013 Mar 4;23(5):430-5 - PubMed
  14. Circulation. 2011 Jul 26;124(4):406-15 - PubMed
  15. Circulation. 1999 Feb 2;99(4):578-88 - PubMed
  16. Biochim Biophys Acta. 2001 Jul 30;1520(1):1-6 - PubMed
  17. JACC Basic Transl Sci. 2018 Feb;3(1):122-131 - PubMed
  18. Am J Pathol. 2016 Aug;186(8):1989-2007 - PubMed
  19. J Biol Chem. 2004 Oct 15;279(42):43382-5 - PubMed
  20. Cardiovasc Res. 2013 Sep 1;99(4):685-93 - PubMed
  21. J Biol Chem. 2013 Mar 29;288(13):8910-21 - PubMed
  22. Eur Heart J. 2008 Jan;29(2):270-6 - PubMed
  23. Acta Biochim Biophys Sin (Shanghai). 2004 Sep;36(9):618-22 - PubMed
  24. Cell Transplant. 2020 Jan-Dec;29:963689720920830 - PubMed
  25. Arch Mal Coeur Vaiss. 2006 Dec;99(12):1236-43 - PubMed
  26. Circulation. 1989 Sep;80(3):564-72 - PubMed
  27. Proc Natl Acad Sci U S A. 2001 Jul 31;98(16):9336-41 - PubMed
  28. Int J Dev Biol. 2000 Aug;44(5):471-7 - PubMed
  29. FASEB J. 2004 Mar;18(3):598-9 - PubMed
  30. Cell Stress Chaperones. 2015 Mar;20(2):207-12 - PubMed
  31. J Biol Chem. 2007 Jan 5;282(1):555-63 - PubMed
  32. Biochem J. 2005 Jun 1;388(Pt 2):475-83 - PubMed
  33. Redox Biol. 2019 Feb;21:101095 - PubMed
  34. Eur Heart J. 2011 May;32(9):1065-76 - PubMed
  35. Int J Vasc Med. 2012;2012:569654 - PubMed
  36. J Mol Cell Cardiol. 2016 Aug;97:245-62 - PubMed
  37. J Neurosci Res. 2008 Feb 1;86(2):264-9 - PubMed
  38. Orphanet J Rare Dis. 2006 Jul 13;1:27 - PubMed
  39. Circ Res. 2002 Nov 29;91(11):1007-14 - PubMed
  40. Mol Cell Biochem. 2004 Oct;265(1-2):71-8 - PubMed
  41. Curr Biol. 2010 Jan 26;20(2):143-8 - PubMed
  42. Cell Stress Chaperones. 2017 Jul;22(4):601-611 - PubMed
  43. J Exp Biol. 2005 Feb;208(Pt 4):697-705 - PubMed
  44. Cell Stress Chaperones. 2004 Summer;9(2):122-33 - PubMed
  45. Free Radic Biol Med. 2019 Jun;137:194-200 - PubMed
  46. PLoS One. 2015 Mar 06;10(3):e0119537 - PubMed
  47. J Biol Chem. 2001 Jul 20;276(29):26753-61 - PubMed
  48. Cardiovasc Res. 2009 Feb 15;81(3):457-64 - PubMed
  49. Heart Fail Rev. 2019 Jan;24(1):143-154 - PubMed
  50. Autophagy. 2008 Feb;4(2):237-9 - PubMed
  51. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1629-1639 - PubMed
  52. Genes Dev. 2008 Jun 1;22(11):1427-38 - PubMed
  53. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1303-10 - PubMed
  54. J Cancer Res Clin Oncol. 2014 Aug;140(8):1305-13 - PubMed
  55. Am J Physiol Heart Circ Physiol. 2001 Jan;280(1):H455-64 - PubMed
  56. J Clin Invest. 2021 Aug 16;131(16): - PubMed
  57. Redox Biol. 2020 Jul;34:101555 - PubMed
  58. J Neurosci Res. 2007 Aug 1;85(10):2071-9 - PubMed
  59. Cell Stress Chaperones. 2007 Winter;12(4):307-19 - PubMed
  60. Free Radic Biol Med. 2012 Jun 1-15;52(11-12):2168-76 - PubMed
  61. Cell Stress Chaperones. 1996 Dec;1(4):251-60 - PubMed
  62. Arch Biochem Biophys. 2006 Oct 1;454(1):32-41 - PubMed
  63. Cell Stress Chaperones. 2003 Spring;8(1):53-61 - PubMed
  64. Prog Neurobiol. 2010 Oct;92(2):184-211 - PubMed
  65. Biochem Biophys Res Commun. 2019 May 14;512(4):698-704 - PubMed
  66. Int J Mol Sci. 2021 Aug 27;22(17): - PubMed
  67. Circ Res. 2004 Aug 20;95(4):433-40 - PubMed
  68. J Exerc Rehabil. 2016 Aug 31;12(4):255-9 - PubMed
  69. Int J Mol Med. 2019 Feb;43(2):821-829 - PubMed
  70. Int J Cardiol. 2016 Aug 15;217:195-204 - PubMed

Publication Types

Grant support