Display options
Cite
Dumesic DA, Padmanabhan V, Chazenbalk GD, et al. Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation. Reprod Biol Endocrinol. 2022;20(1):12doi: 10.1186/s12958-021-00878-y.
Dumesic, D. A., Padmanabhan, V., Chazenbalk, G. D., & Abbott, D. H. (2022). Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation. Reproductive biology and endocrinology : RB&E, 20(1), 12. https://doi.org/10.1186/s12958-021-00878-y
Dumesic, Daniel A, et al. "Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation." Reproductive biology and endocrinology : RB&E vol. 20,1 (2022): 12. doi: https://doi.org/10.1186/s12958-021-00878-y
Dumesic DA, Padmanabhan V, Chazenbalk GD, Abbott DH. Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation. Reprod Biol Endocrinol. 2022 Jan 10;20(1):12. doi: 10.1186/s12958-021-00878-y. PMID: 35012577; PMCID: PMC8744313.
Copy Download .nbib Format: NLM
Share it on

Reprod Biol Endocrinol. 2022 Jan 10;20(1):12. doi: 10.1186/s12958-021-00878-y.

Polycystic ovary syndrome as a plausible evolutionary outcome of metabolic adaptation.

Reproductive biology and endocrinology : RB&E

Daniel A Dumesic, Vasantha Padmanabhan, Gregorio D Chazenbalk, David H Abbott

Affiliations

  1. Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Room 22-178 CHS, Los Angeles, CA, 90095, USA. [email protected].
  2. Department of Pediatrics, University of Michigan, Ann Arbor, MI, 48109, USA.
  3. Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Room 22-178 CHS, Los Angeles, CA, 90095, USA.
  4. Department of Obstetrics and Gynecology, University of Wisconsin and Wisconsin National Primate Research Center, 1223 Capitol Court, Madison, WI, 53715, USA.

PMID: 35012577 PMCID: PMC8744313 DOI: 10.1186/s12958-021-00878-y

Abstract

As a common endocrinopathy of reproductive-aged women, polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, oligo-anovulation and polycystic ovarian morphology. It is linked with insulin resistance through preferential abdominal fat accumulation that is worsened by obesity. Over the past two millennia, menstrual irregularity, male-type habitus and sub-infertility have been described in women and confirm that these clinical features of PCOS were common in antiquity. Recent findings in normal-weight hyperandrogenic PCOS women show that exaggerated lipid accumulation by subcutaneous (SC) abdominal stem cells during development to adipocytes in vitro occurs in combination with reduced insulin sensitivity and preferential accumulation of highly-lipolytic intra-abdominal fat in vivo. This PCOS phenotype may be an evolutionary metabolic adaptation to balance energy storage with glucose availability and fatty acid oxidation for optimal energy use during reproduction. This review integrates fundamental endocrine-metabolic changes in healthy, normal-weight PCOS women with similar PCOS-like traits present in animal models in which tissue differentiation is completed during fetal life as in humans to support the evolutionary concept that PCOS has common ancestral and developmental origins.

© 2022. The Author(s).

Keywords: Adipocyte; Adipose stem cells; Body fat distribution; Developmental programming; Hyperandrogenism; Insulin resistance; Metabolic adaptation; Nonhuman primates; Polycystic ovary syndrome; Sheep

References

  1. J Clin Endocrinol Metab. 2017 Apr 1;102(4):1193-1199 - PubMed
  2. Mol Cell Endocrinol. 2016 Oct 15;434:25-35 - PubMed
  3. Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1837-41 - PubMed
  4. Fertil Steril. 2021 Jul;116(1):232-242 - PubMed
  5. J Pediatr. 1988 Jul;113(1 Pt 1):1-9 - PubMed
  6. Endocrinology. 2016 Feb;157(2):522-35 - PubMed
  7. J Clin Endocrinol Metab. 1994 May;78(5):1052-8 - PubMed
  8. Mol Cell Endocrinol. 2013 Jul 5;373(1-2):39-50 - PubMed
  9. J Clin Endocrinol Metab. 2018 Dec 1;103(12):4465-4477 - PubMed
  10. Endocr Rev. 2015 Oct;36(5):487-525 - PubMed
  11. Cell Metab. 2021 Mar 2;33(3):513-530.e8 - PubMed
  12. J Clin Endocrinol Metab. 2006 Aug;91(8):3105-9 - PubMed
  13. Diabetes. 2019 Jun;68(6):1168-1177 - PubMed
  14. J Clin Endocrinol Metab. 2009 Oct;94(10):3714-20 - PubMed
  15. Nat Rev Endocrinol. 2018 May;14(5):270-284 - PubMed
  16. Obes Rev. 2013 Feb;14(2):95-109 - PubMed
  17. J Clin Endocrinol Metab. 2008 Oct;93(10):3671-89 - PubMed
  18. J Clin Endocrinol Metab. 2019 Apr 30;: - PubMed
  19. Eur J Obstet Gynecol Reprod Biol. 2013 Feb;166(2):151-5 - PubMed
  20. Am J Obstet Gynecol. 1986 May;154(5):1039-43 - PubMed
  21. Biochim Biophys Acta. 2010 Mar;1801(3):209-14 - PubMed
  22. Expert Rev Endocrinol Metab. 2019 Mar;14(2):131-143 - PubMed
  23. Reproduction. 2020 Jan;159(1):R1-R13 - PubMed
  24. J Clin Endocrinol Metab. 2013 Jun;98(6):E1088-96 - PubMed
  25. Sci Rep. 2016 May 23;6:26565 - PubMed
  26. Hum Reprod Update. 2018 Jul 1;24(4):455-467 - PubMed
  27. Biol Reprod. 1983 Mar;28(2):505-16 - PubMed
  28. J Clin Endocrinol Metab. 1997 Apr;82(4):1147-53 - PubMed
  29. PLoS Genet. 2018 Dec 19;14(12):e1007813 - PubMed
  30. Fertil Steril. 2018 Dec;110(7):1367-1376 - PubMed
  31. Reproduction. 2019 Jul;158(1):R27-R40 - PubMed
  32. J Endocrinol. 2004 Nov;183(2):331-42 - PubMed
  33. Med Sci (Basel). 2019 Nov 27;7(12): - PubMed
  34. Nat Med. 2018 Jun;24(6):834-846 - PubMed
  35. Nat Rev Mol Cell Biol. 2011 Sep 28;12(11):722-34 - PubMed
  36. Annu Rev Biochem. 2012;81:715-36 - PubMed
  37. Front Endocrinol (Lausanne). 2020 Apr 30;11:274 - PubMed
  38. Am J Physiol. 1993 Feb;264(2 Pt 1):E197-202 - PubMed
  39. N Engl J Med. 2014 Sep 18;371(12):1131-41 - PubMed
  40. J Exp Biol. 2018 Mar 7;221(Pt Suppl 1): - PubMed
  41. Mol Cell Endocrinol. 2009 Mar 25;301(1-2):97-103 - PubMed
  42. Nat Med. 2020 Feb;26(2):252-258 - PubMed
  43. Biochimie. 2005 Jan;87(1):39-43 - PubMed
  44. Steroids. 2013 Sep;78(9):920-6 - PubMed
  45. Endocrinology. 1970 Oct;87(4):680-7 - PubMed
  46. J Clin Endocrinol Metab. 2006 Jan;91(1):48-53 - PubMed
  47. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1519-27 - PubMed
  48. Nutrients. 2015 Nov 13;7(11):9453-74 - PubMed
  49. J Dev Orig Health Dis. 2018 Jun;9(3):307-314 - PubMed
  50. J Clin Endocrinol Metab. 2016 Nov;101(11):4178-4188 - PubMed
  51. J Clin Endocrinol Metab. 2015 Feb;100(2):661-9 - PubMed
  52. J Clin Endocrinol Metab. 2018 Nov 1;103(11):4315-4323 - PubMed
  53. Hum Reprod Update. 2003 Jul-Aug;9(4):359-72 - PubMed
  54. Diabetes. 2002 Feb;51(2):484-92 - PubMed
  55. Neuroendocrinology. 2019;109(3):218-229 - PubMed
  56. Lancet Child Adolesc Health. 2019 Mar;3(3):166-174 - PubMed
  57. Hum Reprod. 2017 Apr 1;32(4):923-936 - PubMed
  58. J Clin Endocrinol Metab. 2003 May;88(5):2269-73 - PubMed
  59. J Clin Endocrinol Metab. 2019 Jun 1;104(6):2171-2183 - PubMed
  60. Trends Endocrinol Metab. 2009 Nov;20(9):418-23 - PubMed
  61. Hum Reprod. 2002 Oct;17(10):2573-9 - PubMed
  62. Endocrinology. 2014 Jul;155(7):2696-703 - PubMed
  63. Fertil Steril. 2016 Nov;106(6):1510-1520.e2 - PubMed
  64. Am J Gastroenterol. 2019 Nov;114(11):1726-1734 - PubMed
  65. Nature. 2017 Jan 18;541(7637):302-310 - PubMed
  66. Rev Endocr Metab Disord. 2007 Jun;8(2):127-41 - PubMed
  67. Diabetes. 2010 Jan;59(1):105-9 - PubMed
  68. Am J Physiol Endocrinol Metab. 2005 Nov;289(5):E801-6 - PubMed
  69. Hum Reprod Update. 2010 Jul-Aug;16(4):347-63 - PubMed
  70. Endocr Rev. 2012 Dec;33(6):981-1030 - PubMed
  71. J Clin Endocrinol Metab. 2014 Aug;99(8):2942-51 - PubMed
  72. Reprod Biol Endocrinol. 2017 Aug 8;15(1):61 - PubMed
  73. J Clin Endocrinol Metab. 2008 Jan;93(1):162-8 - PubMed
  74. Hum Reprod Update. 2015 Sep-Oct;21(5):575-92 - PubMed
  75. Diabetologia. 2018 Feb;61(2):369-380 - PubMed
  76. J Clin Endocrinol Metab. 2011 Feb;96(2):E304-11 - PubMed
  77. Int J Obes (Lond). 2019 Apr;43(4):673-682 - PubMed
  78. PLoS Biol. 2008 Sep 23;6(9):e237 - PubMed
  79. Curr Opin Endocr Metab Res. 2020 Jun;12:26-32 - PubMed
  80. Am J Dis Child. 1960 Dec;100:818-35 - PubMed
  81. Acta Endocrinol Suppl (Copenh). 1981;241:1-202 - PubMed
  82. J Clin Endocrinol Metab. 2006 Sep;91(9):3654-61 - PubMed
  83. Reprod Sci. 2018 Jul;25(7):1010-1023 - PubMed
  84. J Endocr Soc. 2021 Oct 01;5(11):bvab158 - PubMed
  85. Obstet Gynecol Surv. 2019 Apr;74(4):223-231 - PubMed
  86. Acta Physiol (Oxf). 2014 Apr;210(4):733-53 - PubMed
  87. Nature. 2008 Jun 5;453(7196):783-7 - PubMed
  88. PLoS Med. 2020 Jun 23;17(6):e1003132 - PubMed
  89. J Clin Endocrinol Metab. 2019 Jul 1;104(7):2855-2874 - PubMed
  90. Vet Pathol. 2008 Jul;45(4):512-5 - PubMed
  91. Clin Epigenetics. 2020 Nov 23;12(1):181 - PubMed
  92. J Clin Endocrinol Metab. 2011 Nov;96(11):E1756-60 - PubMed
  93. J Clin Endocrinol Metab. 2016 Jun;101(6):2423-31 - PubMed
  94. Diabetes Care. 1991 Dec;14(12):1132-43 - PubMed
  95. Semin Reprod Med. 2014 May;32(3):159-65 - PubMed
  96. Endocrinology. 2015 Jun;156(6):2323-37 - PubMed
  97. Steroids. 2014 Oct;88:36-43 - PubMed
  98. Lancet. 2010 Jun 26;375(9733):2267-77 - PubMed
  99. Endocr Rev. 2020 Jul 1;41(4): - PubMed
  100. J Clin Endocrinol Metab. 2017 Sep 1;102(9):3327-3339 - PubMed
  101. Hum Reprod. 2018 Sep 1;33(9):1602-1618 - PubMed
  102. J Clin Endocrinol Metab. 2020 Aug 1;105(8): - PubMed
  103. Diabetes Care. 2002 Aug;25(8):1351-7 - PubMed
  104. Endocrinology. 2013 May;154(5):1731-42 - PubMed
  105. Am J Physiol Endocrinol Metab. 2010 Nov;299(5):E741-51 - PubMed
  106. J Clin Endocrinol Metab. 2013 Apr;98(4):1299-306 - PubMed
  107. Clin Endocrinol (Oxf). 2012 Dec;77(6):898-904 - PubMed
  108. Endocrinology. 2010 Feb;151(2):595-605 - PubMed
  109. Diabetologia. 2004 Mar;47(3):420-428 - PubMed
  110. J Endocrinol. 2007 Mar;192(3):585-94 - PubMed

Publication Types

Grant support