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Lv H, Ai D. Hippo/yes-associated protein signaling functions as a mechanotransducer in regulating vascular homeostasis. J Mol Cell Cardiol. 2021;162:158-165doi: 10.1016/j.yjmcc.2021.09.007.
Lv, H., & Ai, D. (2022). Hippo/yes-associated protein signaling functions as a mechanotransducer in regulating vascular homeostasis. Journal of molecular and cellular cardiology, 162158-165. https://doi.org/10.1016/j.yjmcc.2021.09.007
Lv, Huizhen, and Ai, Ding. "Hippo/yes-associated protein signaling functions as a mechanotransducer in regulating vascular homeostasis." Journal of molecular and cellular cardiology vol. 162 (2022): 158-165. doi: https://doi.org/10.1016/j.yjmcc.2021.09.007
Lv H, Ai D. Hippo/yes-associated protein signaling functions as a mechanotransducer in regulating vascular homeostasis. J Mol Cell Cardiol. 2022 Jan;162:158-165. doi: 10.1016/j.yjmcc.2021.09.007. Epub 2021 Sep 20. PMID: 34547259.
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J Mol Cell Cardiol. 2022 Jan;162:158-165. doi: 10.1016/j.yjmcc.2021.09.007. Epub 2021 Sep 20.

Hippo/yes-associated protein signaling functions as a mechanotransducer in regulating vascular homeostasis.

Journal of molecular and cellular cardiology

Huizhen Lv, Ding Ai

Affiliations

  1. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Tianjin Institute of Cardiology, Tianjin Medical University, Tianjin 300070, China; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China.
  2. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Tianjin Key Laboratory of Ion and Molecular Function of Cardiovascular Diseases, Tianjin Institute of Cardiology, Tianjin Medical University, Tianjin 300070, China; Department of Physiology and Pathophysiology, Tianjin Medical University, Tianjin 300070, China. Electronic address: [email protected].

PMID: 34547259 DOI: 10.1016/j.yjmcc.2021.09.007

Abstract

Cells are constantly exposed to various mechanical forces, including hydrostatic pressure, cyclic stretch, fluid shear stress, and extracellular matrix stiffness. Mechanical cues can be translated into the cell-specific transcriptional process by a cellular mechanic-transducer. Evidence suggests that mechanical signals assist activated intracellular signal transduction pathways and the relative phenotypic adaptation to coordinate cell behavior and disease appropriately. The Hippo/yes-associated protein (YAP) signaling pathway is regulated in response to numerous mechanical stimuli. It plays an important role in the mechanotransduction mechanism, which converts mechanical forces to cascades of molecular signaling to modulate gene expression. This review summarizes the recent findings relevant to the Hippo/YAP pathway-based mechanotransduction in cell behavior and maintaining blood vessels, as well as cardiovascular disease.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Hippo/YAP pathway; Mechanical forces; Mechanotransduction; Vascular homeostasis

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