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Gathirua-Mwangi WG, Palmer JR, Champion V, et al. Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women's Health Study. Am J Epidemiol. 2022;doi: 10.1093/aje/kwac004.
Gathirua-Mwangi, W. G., Palmer, J. R., Champion, V., Castro-Webb, N., Stokes, A. C., Adams-Campbell, L., Marley, A. R., Forman, M. R., Rosenberg, L., & Bertrand, K. A. (2022). Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women's Health Study. American journal of epidemiology, . https://doi.org/10.1093/aje/kwac004
Gathirua-Mwangi, Wambui G, et al. "Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women's Health Study." American journal of epidemiology vol. (2022). doi: https://doi.org/10.1093/aje/kwac004
Gathirua-Mwangi WG, Palmer JR, Champion V, Castro-Webb N, Stokes AC, Adams-Campbell L, Marley AR, Forman MR, Rosenberg L, Bertrand KA. Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women's Health Study. Am J Epidemiol. 2022 Jan 11; doi: 10.1093/aje/kwac004. Epub 2022 Jan 11. PMID: 35020804.
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Am J Epidemiol. 2022 Jan 11; doi: 10.1093/aje/kwac004. Epub 2022 Jan 11.

Maximum and Time-Dependent Body Mass Index and Breast Cancer Incidence Among Postmenopausal Women in the Black Women's Health Study.

American journal of epidemiology

Wambui G Gathirua-Mwangi, Julie R Palmer, Victoria Champion, Nelsy Castro-Webb, Andrew C Stokes, Lucile Adams-Campbell, Andrew R Marley, Michele R Forman, Lynn Rosenberg, Kimberly A Bertrand

Affiliations

  1. Eli Lilly and Company.
  2. Slone Epidemiology Center at Boston University, Boston, Massachusetts, United States.
  3. Boston University School of Medicine, Boston, Massachusetts, United States.
  4. School of Nursing, Indiana University School of Nursing, Indianapolis, Indiana, United States.
  5. Department of Global Health, Boston University School of Public Health, Boston, Massachusetts, United States.
  6. Georgetown Lombardi Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, United States.
  7. Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, United States.
  8. Department of Nutrition Science, Purdue University, West Lafayette, Indiana, United States.

PMID: 35020804 DOI: 10.1093/aje/kwac004

Abstract

While excess weight is an established risk factor for postmenopausal breast cancer, consideration of maximum body mass index (maxBMI) or BMI at a point in time relevant for breast carcinogenesis may offer new insights. We prospectively evaluated maxBMI and time-dependent BMI in relation to breast cancer incidence among 31,028 postmenopausal women in the Black Women's Health Study. During 1995-2015, 1,384 diagnoses occurred, including 787 estrogen receptor (ER) positive and 310 ER- cases. BMI was assessed at baseline and 2, 4, 6, and 8 years before diagnosis. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and confidence intervals (CIs). Compared to women with BMI <25 kg/m2, those with BMI ≥35 had increased risk of ER+, but not ER-, breast cancer. For BMI assessed 2 years before diagnosis, the HRs for ER+ breast cancer associated with maxBMI ≥35 and time-dependent BMI ≥35 were 1.42 (95% CI 1.10, 1.83) and 1.63 (95% CI: 1.25, 2.13), respectively. The corresponding HR for time-dependent BMI assessed 6 years before diagnosis was 1.95 (95% CI: 1.45, 2.62). These findings suggest strong associations of BMI with risk of ER+ breast cancer in postmenopausal women regardless of timing of BMI assessment.

© The Author(s) 2022. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: African American; body mass index; breast cancer; epidemiology; lagged analysis; obesity

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