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Schrage B, Zeymer U, Montalescot G, et al. Impact of Center Volume on Outcomes in Myocardial Infarction Complicated by Cardiogenic Shock: A CULPRIT-SHOCK Substudy. J Am Heart Assoc. 2021;10(20):e021150doi: 10.1161/JAHA.120.021150.
Schrage, B., Zeymer, U., Montalescot, G., Windecker, S., Serpytis, P., Vrints, C., Stepinska, J., Savonitto, S., Oldroyd, K. G., Desch, S., Fuernau, G., Huber, K., Noc, M., Schneider, S., Ouarrak, T., Blankenberg, S., Thiele, H., & Clemmensen, P. (2021). Impact of Center Volume on Outcomes in Myocardial Infarction Complicated by Cardiogenic Shock: A CULPRIT-SHOCK Substudy. Journal of the American Heart Association, 10(20), e021150. https://doi.org/10.1161/JAHA.120.021150
Schrage, Benedikt, et al. "Impact of Center Volume on Outcomes in Myocardial Infarction Complicated by Cardiogenic Shock: A CULPRIT-SHOCK Substudy." Journal of the American Heart Association vol. 10,20 (2021): e021150. doi: https://doi.org/10.1161/JAHA.120.021150
Schrage B, Zeymer U, Montalescot G, Windecker S, Serpytis P, Vrints C, Stepinska J, Savonitto S, Oldroyd KG, Desch S, Fuernau G, Huber K, Noc M, Schneider S, Ouarrak T, Blankenberg S, Thiele H, Clemmensen P. Impact of Center Volume on Outcomes in Myocardial Infarction Complicated by Cardiogenic Shock: A CULPRIT-SHOCK Substudy. J Am Heart Assoc. 2021 Oct 19;10(20):e021150. doi: 10.1161/JAHA.120.021150. Epub 2021 Oct 08. PMID: 34622680; PMCID: PMC8751884.
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J Am Heart Assoc. 2021 Oct 19;10(20):e021150. doi: 10.1161/JAHA.120.021150. Epub 2021 Oct 08.

Impact of Center Volume on Outcomes in Myocardial Infarction Complicated by Cardiogenic Shock: A CULPRIT-SHOCK Substudy.

Journal of the American Heart Association

Benedikt Schrage, Uwe Zeymer, Gilles Montalescot, Stephan Windecker, Pranas Serpytis, Christiaan Vrints, Janina Stepinska, Stefano Savonitto, Keith G Oldroyd, Steffen Desch, Georg Fuernau, Kurt Huber, Marko Noc, Steffen Schneider, Taoufik Ouarrak, Stefan Blankenberg, Holger Thiele, Peter Clemmensen

Affiliations

  1. Department of Cardiology University Heart and Vascular Centre Hamburg Hamburg Germany.
  2. DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Luebeck Hamburg Germany.
  3. Department of Cardiology Klinikum der Stadt Ludwigshafen Ludwigshafen am Rhein Germany.
  4. Sorbonne UniversityACTION Study GroupINSERM UMRS 1166Institut de CardiologieHôpital Pitié-Salpêtrière (AP-HP) Paris France.
  5. Department of Cardiology Bern University HospitalInselspitalUniversity of Bern Bern Switzerland.
  6. Clinic of Emergency Medicine Faculty of Medicine VIilnius University Lithuania.
  7. Department of Cardiology Antwerp University Hospital Edegem Belgium.
  8. Department of the Intensive Cardiac Therapy National Institute of Cardiology Warsaw Poland.
  9. Cardiovascular Department Manzoni Hospital Lecco Italy.
  10. West of Scotland Regional Heart and Lung Centre Golden Jubilee National Hospital Glasgow United Kingdom.
  11. Department of Internal Medicine/Cardiology Heart Center Leipzig at University of Leipzig and Leipzig Heart Institute Leipzig Germany.
  12. DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Luebeck Luebeck Germany.
  13. Medical Clinic II (Cardiology, Angiology Intensive Care Medicine) University Heart Center Luebeck Luebeck Germany.
  14. 3rd Department of Medicine Cardiology and Intensive Care Medicine Wilhelminenhospital and Sigmund Freud UniversityMedical Faculty Vienna Austria.
  15. Center for Intensive Internal MedicineUniversity Medical Center Ljubljana Slovenia.
  16. Stiftung Institut für Herzinfarktforschung Ludwigshafen am Rhein Germany.
  17. Department of Regional Research and Department of Medicine Faculty of Health Sciences Nykoebing F HospitalUniversity of Southern Denmark Odense Denmark.

PMID: 34622680 PMCID: PMC8751884 DOI: 10.1161/JAHA.120.021150

Abstract

Background Little is known about the impact of center volume on outcomes in acute myocardial infarction complicated by cardiogenic shock. The aim of this study was to investigate the association between center volume, treatment strategies, and subsequent outcome in patients with acute myocardial infarction complicated by cardiogenic shock. Methods and Results In this subanalysis of the randomized CULPRIT-SHOCK (Culprit Lesion Only PCI Versus Multivessel PCI in Cardiogenic Shock) trial, study sites were categorized based on the annual volume of acute myocardial infarction complicated by cardiogenic shock into low-/intermediate-/high-volume centers (<50; 50-100; and >100 cases/y). Subjects from the study/compulsory registry with available volume data were included. Baseline/procedural characteristics, overall treatment, and 1-year all-cause mortality were compared across categories. n=1032 patients were included in this study (537 treated at low-volume, 240 at intermediate-volume, and 255 at high-volume centers). Baseline risk profile of patients across the volume categories was similar, although high-volume centers included a larger number of older patients. Low-/intermediate-volume centers had more resuscitated patients (57.5%/58.8% versus 42.2%;

Keywords: acute myocardial infarction; cardiogenic shock; center volume; extracorporeal cardiac life support; intensive care

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