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Shapiro AE, Bender Ignacio RA, Whitney BM, et al. Factors associated with severity of COVID-19 disease in a multicenter cohort of people with HIV in the United States, March-December 2020. medRxiv. 2021;doi: 10.1101/2021.10.15.21265063.
Shapiro, A. E., Bender Ignacio, R. A., Whitney, B. M., Delaney, J. A., Nance, R. M., Bamford, L., Wooten, D., Keruly, J. C., Burkholder, G., Napravnik, S., Mayer, K. H., Webel, A. R., Kim, H. N., Van Rompaey, S. E., Christopoulos, K., Jacobson, J., Karris, M., Smith, D., Johnson, M. O., Willig, A., Eron, J. J., Hunt, P., Moore, R. D., Saag, M. S., Mathews, W. C., Crane, H. M., Cachay, E. R., Kitahata, M. M. (2021). Factors associated with severity of COVID-19 disease in a multicenter cohort of people with HIV in the United States, March-December 2020. medRxiv : the preprint server for health sciences, . https://doi.org/10.1101/2021.10.15.21265063
Shapiro, Adrienne E, et al. "Factors associated with severity of COVID-19 disease in a multicenter cohort of people with HIV in the United States, March-December 2020." medRxiv : the preprint server for health sciences vol. (2021). doi: https://doi.org/10.1101/2021.10.15.21265063
Shapiro AE, Bender Ignacio RA, Whitney BM, Delaney JA, Nance RM, Bamford L, Wooten D, Keruly JC, Burkholder G, Napravnik S, Mayer KH, Webel AR, Kim HN, Van Rompaey SE, Christopoulos K, Jacobson J, Karris M, Smith D, Johnson MO, Willig A, Eron JJ, Hunt P, Moore RD, Saag MS, Mathews WC, Crane HM, Cachay ER, Kitahata MM. Factors associated with severity of COVID-19 disease in a multicenter cohort of people with HIV in the United States, March-December 2020. medRxiv. 2021 Oct 18; doi: 10.1101/2021.10.15.21265063. PMID: 34704092; PMCID: PMC8547524.
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medRxiv. 2021 Oct 18; doi: 10.1101/2021.10.15.21265063.

Factors associated with severity of COVID-19 disease in a multicenter cohort of people with HIV in the United States, March-December 2020.

medRxiv : the preprint server for health sciences

Adrienne E Shapiro, Rachel A Bender Ignacio, Bridget M Whitney, Joseph A Delaney, Robin M Nance, Laura Bamford, Darcy Wooten, Jeanne C Keruly, Greer Burkholder, Sonia Napravnik, Kenneth H Mayer, Allison R Webel, H Nina Kim, Stephen E Van Rompaey, Katerina Christopoulos, Jeffrey Jacobson, Maile Karris, Davey Smith, Mallory O Johnson, Amanda Willig, Joseph J Eron, Peter Hunt, Richard D Moore, Michael S Saag, W Christopher Mathews, Heidi M Crane, Edward R Cachay, Mari M Kitahata,

PMID: 34704092 PMCID: PMC8547524 DOI: 10.1101/2021.10.15.21265063

Abstract

BACKGROUND: Understanding the spectrum of SARS-CoV-2 infection and COVID-19 disease in people with HIV (PWH) is critical to provide clinical guidance and implement risk-reduction strategies.

OBJECTIVE: To characterize COVID-19 in PWH in the United States and identify predictors of disease severity.

DESIGN: Observational cohort study.

SETTING: Geographically diverse clinical sites in the CFAR Network of Integrated Clinical Systems (CNICS).

PARTICIPANTS: Adults receiving HIV care through December 31, 2020.

MEASUREMENTS: COVID-19 cases and severity (hospitalization, intensive care, death).

RESULTS: Of 16,056 PWH in care, 649 were diagnosed with COVID-19 between March-December 2020. Case fatality was 2%; 106 (16.3%) were hospitalized and 12 died. PWH with current CD4 count <350 cells/mm

LIMITATIONS: Unable to compare directly to persons without HIV; underestimate of total COVID-19 cases.

CONCLUSIONS: PWH with CD4 <350 cells/mm

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