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Al-Shaikhly T, Murphy RC, Parker A, et al. Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma. Eur Respir J. 2022;doi: 10.1183/13993003.01865-2021.
Al-Shaikhly, T., Murphy, R. C., Parker, A., Lai, Y., Altman, M. C., Larmore, M., Altemeier, W. A., Frevert, C. W., Debley, J. S., Piliponsky, A. M., Ziegler, S. F., Peters, M. C., & Hallstrand, T. S. (2022). Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma. The European respiratory journal, . https://doi.org/10.1183/13993003.01865-2021
Al-Shaikhly, Taha, et al. "Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma." The European respiratory journal vol. (2022). doi: https://doi.org/10.1183/13993003.01865-2021
Al-Shaikhly T, Murphy RC, Parker A, Lai Y, Altman MC, Larmore M, Altemeier WA, Frevert CW, Debley JS, Piliponsky AM, Ziegler SF, Peters MC, Hallstrand TS. Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma. Eur Respir J. 2022 Jan 13; doi: 10.1183/13993003.01865-2021. Epub 2022 Jan 13. PMID: 35027395.
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Eur Respir J. 2022 Jan 13; doi: 10.1183/13993003.01865-2021. Epub 2022 Jan 13.

Location of eosinophils in the airway wall is critical for specific features of airway hyperresponsiveness and T2 inflammation in asthma.

The European respiratory journal

Taha Al-Shaikhly, Ryan C Murphy, Andrew Parker, Ying Lai, Matthew C Altman, Megan Larmore, William A Altemeier, Charles W Frevert, Jason S Debley, Adrian M Piliponsky, Steven F Ziegler, Michael C Peters, Teal S Hallstrand

Affiliations

  1. Division of Allergy and Infectious Diseases, University of Washington, Seattle, Washington, USA.
  2. Center for Lung Biology, University of Washington, Seattle, Washington, USA.
  3. Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA.
  4. Immunology Program, Benaroya Research Institute, Seattle, Washington, USA.
  5. Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
  6. Division of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA.
  7. Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA.
  8. Division of Pulmonary and Critical Care, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
  9. Center for Lung Biology, University of Washington, Seattle, Washington, USA [email protected].

PMID: 35027395 DOI: 10.1183/13993003.01865-2021

Abstract

Eosinophils are implicated as effector cells in asthma but the functional implications of the precise location of eosinophils in the airway wall is poorly understood. We aimed to quantify eosinophils in the different compartments of the airway wall and associate these findings with clinical features of asthma and markers of airway inflammation.In this cross-sectional study, we utilised design-based stereology to accurately partition the numerical density of eosinophils in both the epithelial compartment and the subepithelial space (airway wall area below the basal lamina including the submucosa) in individuals with and without asthma and related these findings to airway hyperresponsiveness (AHR) and features of airway inflammation.Intraepithelial eosinophils were linked to the presence of asthma and endogenous AHR, the type of AHR that is most specific for asthma. In contrast, both intraepithelial and subepithelial eosinophils were associated with type-2 (T2) inflammation, with the strongest association between

Copyright ©The authors 2022. For reproduction rights and permissions contact [email protected].

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