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Norris AJ, Shaker JR, Cone AL, et al. Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses. Elife. 2021;10doi: 10.7554/eLife.60779.
Norris, A. J., Shaker, J. R., Cone, A. L., Ndiokho, I. B., & Bruchas, M. R. (2021). Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses. eLife, 10. https://doi.org/10.7554/eLife.60779
Norris, Aaron J, et al. "Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses." eLife vol. 10 (2021). doi: https://doi.org/10.7554/eLife.60779
Norris AJ, Shaker JR, Cone AL, Ndiokho IB, Bruchas MR. Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses. Elife. 2021 Mar 05;10. doi: 10.7554/eLife.60779. PMID: 33667158; PMCID: PMC7935488.
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Elife. 2021 Mar 05;10. doi: 10.7554/eLife.60779.

Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses.

eLife

Aaron J Norris, Jordan R Shaker, Aaron L Cone, Imeh B Ndiokho, Michael R Bruchas

Affiliations

  1. Department of Anesthesiology, Washington University School of Medicine, St. Louis, United States.
  2. Medical Scientist Training Program, University of Washington, Seattle, United States.
  3. Center for the Neurobiology of Addiction, Pain and Emotion, Departments of Anesthesiology and Pharmacology, University of Washington, Seattle, United States.

PMID: 33667158 PMCID: PMC7935488 DOI: 10.7554/eLife.60779

Abstract

Maintaining stable body temperature through environmental thermal stressors requires detection of temperature changes, relay of information, and coordination of physiological and behavioral responses. Studies have implicated areas in the preoptic area of the hypothalamus (POA) and the parabrachial nucleus (PBN) as nodes in the thermosensory neural circuitry and indicate that the opioid system within the POA is vital in regulating body temperature. In the present study we identify neurons projecting to the POA from PBN expressing the opioid peptides dynorphin and enkephalin. Using mouse models, we determine that warm-activated PBN neuronal populations overlap with both prodynorphin (Pdyn) and proenkephalin (Penk) expressing PBN populations. Here we report that in the PBN

© 2021, Norris et al.

Keywords: mouse; neuroscience; optogenetics; parabrachial nucelus; preoptic area; temperature regualtion; thermal defense

Conflict of interest statement

AN, JS, AC, IN, MB No competing interests declared

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