Display options
Cite
Le Page L, Baldwin CL, Telfer JC. γδ T cells in artiodactyls: Focus on swine. Dev Comp Immunol. 2021;128:104334doi: 10.1016/j.dci.2021.104334.
Le Page, L., Baldwin, C. L., & Telfer, J. C. (2022). γδ T cells in artiodactyls: Focus on swine. Developmental and comparative immunology, 128104334. https://doi.org/10.1016/j.dci.2021.104334
Le Page, Lauren, et al. "γδ T cells in artiodactyls: Focus on swine." Developmental and comparative immunology vol. 128 (2022): 104334. doi: https://doi.org/10.1016/j.dci.2021.104334
Le Page L, Baldwin CL, Telfer JC. γδ T cells in artiodactyls: Focus on swine. Dev Comp Immunol. 2022 Mar;128:104334. doi: 10.1016/j.dci.2021.104334. Epub 2021 Dec 15. PMID: 34919982.
Copy Download .nbib Format: NLM
Share it on

Dev Comp Immunol. 2022 Mar;128:104334. doi: 10.1016/j.dci.2021.104334. Epub 2021 Dec 15.

γδ T cells in artiodactyls: Focus on swine.

Developmental and comparative immunology

Lauren Le Page, Cynthia L Baldwin, Janice C Telfer

Affiliations

  1. Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA, 01003, USA.
  2. Department of Veterinary & Animal Sciences, University of Massachusetts, Amherst, MA, 01003, USA. Electronic address: [email protected].

PMID: 34919982 DOI: 10.1016/j.dci.2021.104334

Abstract

Vaccination is the most effective medical strategy for disease prevention but there is a need to improve livestock vaccine efficacy. Understanding the structure of the immune system of swine, which are considered a γδ T cell "high" species, and thus, particularly how to engage their γδ T cells for immune responses, may allow for development of vaccine optimization strategies. The propensity of γδ T cells to home to specific tissues, secrete pro-inflammatory and regulatory cytokines, exhibit memory or recall responses and even function as antigen-presenting cells for αβ T cells supports the concept that they have enormous potential for priming by next generation vaccine constructs to contribute to protective immunity. γδ T cells exhibit several innate-like antigen recognition properties including the ability to recognize antigen in the absence of presentation via major histocompatibility complex (MHC) molecules enabling γδ T cells to recognize an array of peptides but also non-peptide antigens in a T cell receptor-dependent manner. γδ T cell subpopulations in ruminants and swine can be distinguished based on differential expression of the hybrid co-receptor and pattern recognition receptors (PRR) known as workshop cluster 1 (WC1). Expression of various PRR and other innate-like immune receptors diversifies the antigen recognition potential of γδ T cells. Finally, γδ T cells in livestock are potent producers of critical master regulator cytokines such as interferon (IFN)-γ and interleukin (IL)-17, whose production orchestrates downstream cytokine and chemokine production by other cells, thereby shaping the immune response as a whole. Our knowledge of the biology, receptor expression and response to infectious diseases by swine γδ T cells is reviewed here.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: IFNγ; IL-17; Pathogens; Ruminants; Swine; WC1; γδ T cells

Publication Types