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Harris HR, Korkes KMN, Li T, et al. Endometriosis, psoriasis and psoriatic arthritis: A prospective cohort study. Am J Epidemiol. 2022;doi: 10.1093/aje/kwac009.
Harris, H. R., Korkes, K. M. N., Li, T., Kvaskoff, M., Cho, E., Carvalho, L. F., Qureshi, A. A., Abrao, M., & Missmer, S. A. (2022). Endometriosis, psoriasis and psoriatic arthritis: A prospective cohort study. American journal of epidemiology, . https://doi.org/10.1093/aje/kwac009
Harris, Holly R, et al. "Endometriosis, psoriasis and psoriatic arthritis: A prospective cohort study." American journal of epidemiology vol. (2022). doi: https://doi.org/10.1093/aje/kwac009
Harris HR, Korkes KMN, Li T, Kvaskoff M, Cho E, Carvalho LF, Qureshi AA, Abrao M, Missmer SA. Endometriosis, psoriasis and psoriatic arthritis: A prospective cohort study. Am J Epidemiol. 2022 Jan 13; doi: 10.1093/aje/kwac009. Epub 2022 Jan 13. PMID: 35029650.
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Am J Epidemiol. 2022 Jan 13; doi: 10.1093/aje/kwac009. Epub 2022 Jan 13.

Endometriosis, psoriasis and psoriatic arthritis: A prospective cohort study.

American journal of epidemiology

Holly R Harris, Karen Moreno Nascimento Korkes, Tricia Li, Marina Kvaskoff, Eunyoung Cho, Luiz Fernando Carvalho, Abrar A Qureshi, Mauricio Abrao, Stacey A Missmer

Affiliations

  1. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  2. Department of Epidemiology, University of Washington, Seattle, Washington.
  3. Gynecologic Division, Hospital das Cl?nicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
  4. Department of Dermatology, Warren Alpert Medical School of Brown University, Providence, Rhode Island.
  5. Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
  6. Université Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" Team, CESP, 94805, Villejuif, France.
  7. Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island.
  8. Department of Dermatology, Rhode Island Hospital, Providence, Rhode  Island.
  9. Gynecologic Division, BP ~ A Beneficencia Portuguesa de Sao Paulo, Sao Paulo, Brazil.
  10. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
  11. Department of Obstetrics, Gynecology, and Reproductive Biology; College of Human Medicine, Michigan State University, Grand Rapids, Michigan.

PMID: 35029650 DOI: 10.1093/aje/kwac009

Abstract

Endometriosis, psoriasis and psoriatic arthritis (PsA) are chronic inflammatory disorders that have etiologies that remain poorly understood but may be correlated, as endometriosis has been associated with other inflammatory disorders. We investigated the bi-directional associations between laparoscopically-confirmed endometriosis, and physician-diagnosed psoriasis and PsA in the Nurses' Health Study II cohort (n=116,429 aged 25-42 years in 1989). During 22 years of follow-up (1991-2013), 4,112 incident cases of laparoscopically-confirmed endometriosis (mean age at diagnosis=40.3 years) and 697 validated physician-diagnosed cases of psoriasis (mean age at diagnosis=43.6 years), 110 of whom had concomitant PsA, were confirmed. A history of psoriasis with concomitant PsA was associated with a 2-fold higher risk of endometriosis (HR=2.01, 95% CI=1.23-3.30), however no association was observed between psoriasis without PsA and endometriosis risk (HR=0.93, 95% CI=0.68-1.26). When endometriosis was the exposure, it was not associated with a risk of subsequent psoriasis (HR=1.28, 95% CI=0.95-1.72). The risk of psoriasis with PsA was notably higher, however the sample size was small with wide confidence intervals (HR=1.77, 95% CI=0.89-3.52). Our findings suggest that psoriasis with concomitant PsA is associated with greater risk of laparoscopically-confirmed endometriosis. In addition, there was a suggestive association between endometriosis diagnosis and subsequent risk of psoriasis with PsA.

© The Author(s) 2022. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: [email protected].

Keywords: cohort study; endometriosis; psoriasis; psoriatic arthritis

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