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Vauzelle C. Amoxicilline-acide clavulanique (Augmentin®) en fin de grossesse. [Amoxicillin-clavulanic acid in late pregnancy]. Gynecol Obstet Fertil Senol. 2021;doi: 10.1016/j.gofs.2021.12.008.
Vauzelle, C. (2021). Amoxicilline-acide clavulanique (Augmentin®) en fin de grossesse. [Amoxicillin-clavulanic acid in late pregnancy]. Gynecologie, obstetrique, fertilite & senologie, . https://doi.org/10.1016/j.gofs.2021.12.008
Vauzelle, C. "Amoxicilline-acide clavulanique (Augmentin®) en fin de grossesse." [Amoxicillin-clavulanic acid in late pregnancy]. Gynecologie, obstetrique, fertilite & senologie vol. (2021). doi: https://doi.org/10.1016/j.gofs.2021.12.008
Vauzelle C. Amoxicilline-acide clavulanique (Augmentin®) en fin de grossesse. [Amoxicillin-clavulanic acid in late pregnancy]. Gynecol Obstet Fertil Senol. 2021 Dec 24; doi: 10.1016/j.gofs.2021.12.008. Epub 2021 Dec 24. French. PMID: 34954405.
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Gynecol Obstet Fertil Senol. 2021 Dec 24; doi: 10.1016/j.gofs.2021.12.008. Epub 2021 Dec 24.

[Amoxicillin-clavulanic acid in late pregnancy].

Gynecologie, obstetrique, fertilite & senologie

[Article in French]
C Vauzelle

Affiliations

  1. Centre de référence sur les agents tératogènes (CRAT), DMU ESPRIT (Epidémiologie et biostatistique, Santé publique, Pharmacie, Pharmacologie, Recherche, Information médicale, Thérapeutique et médicaments), GHU, Sorbonne Université, AP-HP, site Trousseau, 26, avenue Docteur-Netter, 75571 Paris cedex 12, France. Electronic address: [email protected].

PMID: 34954405 DOI: 10.1016/j.gofs.2021.12.008

Abstract

In 2001, a clinical trial on prophylactic antibiotics in preterm prelabor rupture of membranes reported an increased risk of necrotizing enterocolitis in newborns whose mothers were given amoxicillin-clavulanic acid before delivery. This study generated concern and reluctance to use this antibiotic in late pregnancy, despite its methodological limitations and the lack of confirmation in 3 studies published between 2001 and 2008. Since then, there have been no original publications on the topic. Therefore, the results available to date do not support an increased risk of necrotizing enterocolitis with the use of amoxicillin-clavulanic acid in late pregnancy. In clinical situations where amoxicillin/clavulanic acid is required, it can be prescribed at any stage of pregnancy, including just before delivery.

Copyright © 2021 Elsevier Masson SAS. All rights reserved.

Keywords: Acide clavulanique; Augmentin®; Clavulanic acid; Entérocolite ulcéronécrosante; Grossesse; Necrotizing enterocolitis; Newborn; Nouveau-né; Pregnancy

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