Display options
Cite
Carboni L, El Khoury A, Beiderbeck DI, et al. Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours. Eur Neuropsychopharmacol. 2022;57:1-14doi: 10.1016/j.euroneuro.2021.12.011.
Carboni, L., El Khoury, A., Beiderbeck, D. I., Neumann, I. D., & Mathé, A. A. (2022). Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 571-14. https://doi.org/10.1016/j.euroneuro.2021.12.011
Carboni, Lucia, et al. "Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours." European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology vol. 57 (2022): 1-14. doi: https://doi.org/10.1016/j.euroneuro.2021.12.011
Carboni L, El Khoury A, Beiderbeck DI, Neumann ID, Mathé AA. Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours. Eur Neuropsychopharmacol. 2022 Jan 07;57:1-14. doi: 10.1016/j.euroneuro.2021.12.011. Epub 2022 Jan 07. PMID: 35008014.
Copy Download .nbib Format: NLM
Share it on

Eur Neuropsychopharmacol. 2022 Jan 07;57:1-14. doi: 10.1016/j.euroneuro.2021.12.011. Epub 2022 Jan 07.

Neuropeptide Y, calcitonin gene-related peptide, and neurokinin A in brain regions of HAB rats correlate with anxiety-like behaviours.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

Lucia Carboni, Aram El Khoury, Daniela I Beiderbeck, Inga D Neumann, Aleksander A Mathé

Affiliations

  1. Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Bologna, Italy. Electronic address: [email protected].
  2. Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden.
  3. Department of Behavioural and Molecular Neurobiology, University of Regensburg, 93040, Regensburg, Germany.

PMID: 35008014 DOI: 10.1016/j.euroneuro.2021.12.011

Abstract

Anxiety disorders are pervasive psychiatric disorders causing great suffering. The high (HAB) and low (LAB) anxiety-related behaviour rats were selectively bred to investigate neurobiological correlates of anxiety. We compared the level of neuropeptides relevant for anxiety- and depression-related behaviours in selected brain regions of HAB and LAB rats. Increased anxiety and depression-like behaviours of male and female HAB rats in the elevated plus-maze and forced swim tests were accompanied by elevated levels of neuropeptide Y (NPY) in the prefrontal (PFC), frontal (FC) and cingulate cortex (CCx), the striatum, and periaqueductal grey (PAG). Moreover, HAB rats displayed sex-dependent, elevated levels of calcitonin gene-related peptide (CGRP) in PFC, FC, CCx, hippocampus, and PAG. Higher neurokinin A (NKA) levels were detected in CCx, striatum, and PAG in HAB males and in CCx and hypothalamus in HAB females. Increased neurotensin was detected in CCx and PAG in HAB males and in hypothalamus in HAB females. Elevated corticotropin-releasing hormone (CRH) levels appeared in female HAB hypothalamus. Significant correlations were found between anxiety-like behaviour and NPY, CGRP, NKA, and neurotensin, particularly with NPY in CCx and striatum, CGRP in FC and hippocampus, and NKA in entorhinal cortex. This is the first report of NPY, CGRP, NKA, Neurotensin, and CRH measurements in brain regions of HAB and LAB rats, which showed widespread NPY and CGRP alterations in cortical regions, with NKA and neurotensin changes localised in sub-cortical areas. The results may contribute to elucidate pathophysiological mechanisms underlying anxiety and depression and should facilitate identifying novel therapeutic targets.

Copyright © 2021. Published by Elsevier B.V.

Keywords: CGRP; Corticotropin releasing hormone; HAB LAB rats; NPY; Neurokinin A; Neurotensin

Conflict of interest statement

Conflict of Interest The authors declare that they have no conflicts of interest.

Publication Types