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Roy D, Jenkins B, Ali A, et al. Multi-component redox system for selective and potent antineoplastic activity towards ovarian cancer cells. Biochem Biophys Res Commun. 2022;592:38-43doi: 10.1016/j.bbrc.2022.01.007.
Roy, D., Jenkins, B., Ali, A., Herschmann, J. R., Harris, M., Zamadar, M., Simington, L., Odunuga, O., Adhikari, P., Pradhan, P., Sarkar, S., Pattabiram, M., & Sengupta, B. (2022). Multi-component redox system for selective and potent antineoplastic activity towards ovarian cancer cells. Biochemical and biophysical research communications, 59238-43. https://doi.org/10.1016/j.bbrc.2022.01.007
Roy, Debarshi, et al. "Multi-component redox system for selective and potent antineoplastic activity towards ovarian cancer cells." Biochemical and biophysical research communications vol. 592 (2022): 38-43. doi: https://doi.org/10.1016/j.bbrc.2022.01.007
Roy D, Jenkins B, Ali A, Herschmann JR, Harris M, Zamadar M, Simington L, Odunuga O, Adhikari P, Pradhan P, Sarkar S, Pattabiram M, Sengupta B. Multi-component redox system for selective and potent antineoplastic activity towards ovarian cancer cells. Biochem Biophys Res Commun. 2022 Jan 06;592:38-43. doi: 10.1016/j.bbrc.2022.01.007. Epub 2022 Jan 06. PMID: 35026603.
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Biochem Biophys Res Commun. 2022 Jan 06;592:38-43. doi: 10.1016/j.bbrc.2022.01.007. Epub 2022 Jan 06.

Multi-component redox system for selective and potent antineoplastic activity towards ovarian cancer cells.

Biochemical and biophysical research communications

Debarshi Roy, Brenita Jenkins, Aqeeb Ali, Jacob R Herschmann, Michele Harris, Matibur Zamadar, Laken Simington, Odutayo Odunuga, Prakash Adhikari, Prabhakar Pradhan, Sanjay Sarkar, Mahesh Pattabiram, Bidisha Sengupta

Affiliations

  1. Department of Biological Sciences, Alcorn State University, Lorman, MS, USA. Electronic address: [email protected].
  2. Department of Biological Sciences, Alcorn State University, Lorman, MS, USA.
  3. Department of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA.
  4. Department of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA. Electronic address: [email protected].
  5. Department of Physics and Astronomy, Mississippi State University, Mississippi State, MS, USA.
  6. Department of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  7. Department of Chemistry, University of Nebraska Kearney, Kearney, NE, USA.
  8. Department of Chemistry and Biochemistry, Stephen F. Austin State University, Nacogdoches, TX, USA. Electronic address: [email protected].

PMID: 35026603 DOI: 10.1016/j.bbrc.2022.01.007

Abstract

Ovarian cancer is the deadliest gynecological cancer which rarely causes symptoms, and goes undetected until reaching the advanced stage of drug-resistant metastases. The cationic porphyrin meso-tetra(4-N-methylpyridyl)porphine (TMPyP) is a well-known photosensitizer (PS) used in photodyamic therapy (PDT) for curing cancer due to its strong affinity for DNA and high yield of reactive oxygen species (ROS) upon light activation. The practicality to irradiate tumor cells alone in the physiological system being slim (due to the close proximity of healthy cells and tumors), we looked for a variation in the PDT using a mixture of TMPyP with 1,5-dihydroxynapthalene (DHN) and Fe(III) ions at a mole ratio of 1:20:17 (drug combo) respectively in aqueous solution. The drug combo needs no photoactivation in H

Copyright © 2022. Published by Elsevier Inc.

Keywords: Juglone; Oxidative stress; Reactive oxygen species; Singlet oxygen

Conflict of interest statement

Declaration of competing interest The authors whose names are listed immediately below certify that they have NO affiliations with or involvement in any organization or entity with any financial inter

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