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Rubio TA, Rodrigues B, da Costa LMC, et al. Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives. Exp Gerontol. 2022;159:111686doi: 10.1016/j.exger.2021.111686.
Rubio, T. A., Rodrigues, B., da Costa, L. M. C., Ferreira-Melo, S. E., Tacito, L. H. B., Moreno, B., Martin, J. F. V., Cestario, E. D. E. S., Godoy, M. F., Moreno-Junior, H., & Yugar-Toledo, J. C. (2022). Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives. Experimental gerontology, 159111686. https://doi.org/10.1016/j.exger.2021.111686
Rubio, Tatiane Azevedo, et al. "Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives." Experimental gerontology vol. 159 (2022): 111686. doi: https://doi.org/10.1016/j.exger.2021.111686
Rubio TA, Rodrigues B, da Costa LMC, Ferreira-Melo SE, Tacito LHB, Moreno B, Martin JFV, Cestario EDES, Godoy MF, Moreno-Junior H, Yugar-Toledo JC. Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives. Exp Gerontol. 2022 Jan 05;159:111686. doi: 10.1016/j.exger.2021.111686. Epub 2022 Jan 05. PMID: 34995726.
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Exp Gerontol. 2022 Jan 05;159:111686. doi: 10.1016/j.exger.2021.111686. Epub 2022 Jan 05.

Linear and non-linear analyses of autonomic modulation in uncontrolled and controlled elderly resistant hypertensives.

Experimental gerontology

Tatiane Azevedo Rubio, Bruno Rodrigues, Larissa Morete Caieiro da Costa, Silvia Elaine Ferreira-Melo, Lucia Helena Bonalume Tacito, Beatriz Moreno, José Fernando Vilela Martin, Elizabeth do Espírito Santo Cestario, Moacir Fernandes Godoy, Heitor Moreno-Junior, Juan Carlos Yugar-Toledo

Affiliations

  1. Hypertension Clinic, Internal Medicine Department, Medical School of São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil.
  2. Laboratory of Cardiovascular Investigation & Exercise, School of Physical Education, University of Campinas (UNICAMP), Campinas, SP, Brazil.
  3. Cardiovascular Pharmacology & Hypertension Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
  4. Surgery and Clinical Divisions, Medical School of São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil.
  5. Hypertension Clinic, Internal Medicine Department, Medical School of São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil. Electronic address: [email protected].

PMID: 34995726 DOI: 10.1016/j.exger.2021.111686

Abstract

Resistant hypertension (RHT) is associated with worse outcomes among patients, and sympathetic overactivity is a challenge in treating this clinical condition. Here, we evaluated the autonomic modulation (by linear and non-linear analyses), central blood pressure, and pulse wave velocity in controlled and uncontrolled RHT patients, as well as those in use of beta-blockers. We observed that uncontrolled RHT patients display, in addition to an increase in peripheral blood pressure, presented higher central blood pressure values concerning controlled RHT. Furthermore, despite the use of beta-blockers, both patients in the RHT + beta-blockers and uncontrolled RHT groups had negative changes in autonomic balance as compared with controlled RHT. These results reinforce the importance of autonomic nervous system interventions in managing arterial hypertension.

Copyright © 2021. Published by Elsevier Inc.

Keywords: Arterial stiffness; Central blood pressure; Heart rate variability; Hypertension

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