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Passia E, Vis M, Coates LC, et al. Sex-specific differences and how to handle them in early psoriatic arthritis. Arthritis Res Ther. 2022;24(1):22doi: 10.1186/s13075-021-02680-y.
Passia, E., Vis, M., Coates, L. C., Soni, A., Tchetverikov, I., Gerards, A. H., Kok, M. R., Vos, P. A. J. M., Korswagen, L., Fodili, F., Goekoop-Ruiterman, Y. P. M., van der Kaap, J., van Oosterhout, M., & Luime, J. J. (2022). Sex-specific differences and how to handle them in early psoriatic arthritis. Arthritis research & therapy, 24(1), 22. https://doi.org/10.1186/s13075-021-02680-y
Passia, E, et al. "Sex-specific differences and how to handle them in early psoriatic arthritis." Arthritis research & therapy vol. 24,1 (2022): 22. doi: https://doi.org/10.1186/s13075-021-02680-y
Passia E, Vis M, Coates LC, Soni A, Tchetverikov I, Gerards AH, Kok MR, Vos PAJM, Korswagen L, Fodili F, Goekoop-Ruiterman YPM, van der Kaap J, van Oosterhout M, Luime JJ. Sex-specific differences and how to handle them in early psoriatic arthritis. Arthritis Res Ther. 2022 Jan 11;24(1):22. doi: 10.1186/s13075-021-02680-y. PMID: 35016726; PMCID: PMC8751248.
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Arthritis Res Ther. 2022 Jan 11;24(1):22. doi: 10.1186/s13075-021-02680-y.

Sex-specific differences and how to handle them in early psoriatic arthritis.

Arthritis research & therapy

E Passia, M Vis, L C Coates, A Soni, I Tchetverikov, A H Gerards, M R Kok, P A J M Vos, L Korswagen, F Fodili, Y P M Goekoop-Ruiterman, J van der Kaap, M van Oosterhout, J J Luime

Affiliations

  1. Department of Rheumatology, Erasmus University MC, NB 850, PO box 2040, 3315EJ, Rotterdam, The Netherlands.
  2. Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, Un. of Oxford, Oxford, UK.
  3. Albert Schweitzer H., Dordrecht, The Netherlands.
  4. Fransicus H., Rotterdam, The Netherlands.
  5. Maasstad H., Rotterdam, The Netherlands.
  6. Amphia H., Breda, The Netherlands.
  7. Reumazorg Zuid West Nederland, Roosendaal, The Netherlands.
  8. Haga H., Den Haag, Hague, The Netherlands.
  9. Groene Hart H., Gouda, The Netherlands.
  10. Department of Rheumatology, Erasmus University MC, NB 850, PO box 2040, 3315EJ, Rotterdam, The Netherlands. [email protected].

PMID: 35016726 PMCID: PMC8751248 DOI: 10.1186/s13075-021-02680-y

Abstract

OBJECTIVES: The prevalence of psoriatic arthritis (PsA) is the same in men and women; however, the latter experience a higher burden of disease and are affected more frequently by polyarthritis. Here, we performed an early PsA cohort analysis to assess sex-related differences in demographics, disease characteristics, and evolution over 1 year including applied treatment strategies.

METHODS: Our study is embedded in the Dutch south-west Early Psoriatic Arthritis cohoRt. We described patient characteristics and treatment decisions. For the comparison across sexes and baseline and 1 year follow-up, appropriate tests depending on the distribution were used.

RESULTS: Two hundred seventy-three men and 294 women with no significant differences in age and ethnicity were included. Women reported significantly longer duration of symptoms before diagnosis and significantly higher tender joint count, a higher disease activity, higher levels of pain, and lower functional capacity. Although minimal disease activity (MDA) rates increased over time for both sexes, MDA remained significantly more prevalent among men at 1 year (58.1% vs 35.7%, p < 0.00). Initially, treatment strategies were similar in both sexes with methotrexate being the most frequently used drug during the first year. Women received methotrexate for a shorter period [196 (93-364) vs 306 (157-365), p < 0.00] and therefore received a lower cumulative dose compared to men. Retention time was shorter for all DMARDs, and women had a delayed start on b-DMARDs.

CONCLUSION: After 1 year of standard-of-care treatment, women did not surpass their baseline disadvantages. Despite the overall improvement, they still presented higher disease activity, higher levels of pain, and lower functional capacity score than men. The nature of these findings may advocate a need for sex specific adjustment of treatment strategies and evaluation in early PsA patients.

© 2022. The Author(s).

Keywords: Psoriatic arthritis; Sex differences

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