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El Alami H, Ghazal H, Abidi O, et al. Relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and susceptibility to type 2 diabetes mellitus in the Middle East and North Africa Region: A meta-analysis. Diabetes Metab Syndr. 2022;16(1):102386doi: 10.1016/j.dsx.2021.102386.
El Alami, H., Ghazal, H., Abidi, O., Al Idrissi, N., Wakrim, L., Naamane, A., Khlil, N., & Hamdi, S. (2022). Relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and susceptibility to type 2 diabetes mellitus in the Middle East and North Africa Region: A meta-analysis. Diabetes & metabolic syndrome, 16(1), 102386. https://doi.org/10.1016/j.dsx.2021.102386
El Alami, Houda, et al. "Relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and susceptibility to type 2 diabetes mellitus in the Middle East and North Africa Region: A meta-analysis." Diabetes & metabolic syndrome vol. 16,1 (2022): 102386. doi: https://doi.org/10.1016/j.dsx.2021.102386
El Alami H, Ghazal H, Abidi O, Al Idrissi N, Wakrim L, Naamane A, Khlil N, Hamdi S. Relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and susceptibility to type 2 diabetes mellitus in the Middle East and North Africa Region: A meta-analysis. Diabetes Metab Syndr. 2022 Jan 07;16(1):102386. doi: 10.1016/j.dsx.2021.102386. Epub 2022 Jan 07. PMID: 35033991.
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Diabetes Metab Syndr. 2022 Jan 07;16(1):102386. doi: 10.1016/j.dsx.2021.102386. Epub 2022 Jan 07.

Relationship between insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) gene and susceptibility to type 2 diabetes mellitus in the Middle East and North Africa Region: A meta-analysis.

Diabetes & metabolic syndrome

Houda El Alami, Hassan Ghazal, Omar Abidi, Najib Al Idrissi, Lahcen Wakrim, Abderrahmane Naamane, Naima Khlil, Salsabil Hamdi

Affiliations

  1. Environmental Health Laboratory, Institut Pasteur du Maroc, Morocco; Laboratory of Chemistry, Biochemistry, Nutrition, and Environment, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco.
  2. National Center for Scientific and Technical Research, Rabat, Morocco.
  3. Higher Institute of Nursing Professions and Health Techniques, Casablanca, Ministry of Health, Morocco.
  4. Department of Surgery, School of Medicine, Mohammed VI University of Health Sciences, Casablanca, Morocco, Hospital Cheikh Khalifa, Casablanca, Morocco.
  5. Virology Unit, Immunovirology Laboratory, Institut Pasteur du Maroc, Casablanca, Morocco.
  6. Laboratory of Chemistry, Biochemistry, Nutrition, and Environment, Faculty of Medicine and Pharmacy, University Hassan II, Casablanca, Morocco.
  7. Environmental Health Laboratory, Institut Pasteur du Maroc, Morocco. Electronic address: [email protected].

PMID: 35033991 DOI: 10.1016/j.dsx.2021.102386

Abstract

BACKGROUND AND AIMS: The association between insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene and the risk of type 2 diabetes mellitus (T2DM) remains controversial. This study aimed to assess the effect of the ACE I/D gene polymorphism on T2DM in the Middle East and North Africa region (MENA region).

MATERIAL AND METHODS: Our data was extracted from PubMed, Science Direct, and the Web of Science. The predefined inclusion criteria included only the human case-control studies of English Peer-reviewed papers containing the data on genotype distributions of ACE I/D polymorphism and the T2DM risk. Review articles, meeting abstracts, editorials, animal studies, and studies not providing genotype distribution data or without sufficient data were excluded from this work. Results of this meta-analysis were expressed using odds ratios (OR) and 95% confidence intervals (CI). Indeed, the potential sources of heterogeneity and bias were examined by the Egger regression.

RESULTS: Of 2755 identified articles, 10 studies were selected, including 2710 patients with T2DM and 2504 control subjects. Overall, we found a significant increased risk of T2DM susceptibility and the D allele of ACE I/D gene polymorphism (OR = 1.97; 95% CI = 1.33-2.93, p = 0.0007), recessive (OR = 2.16; 95% CI = 1.27-3.67; p = 0.004), dominant (OR = 2.45; 95% CI = 1.54-3.91; p = 0.0001), homozygote (OR = 3.35; 95% CI = 1.78-6.29; p = 0.0001) and heterozygote comparisons (OR = 1.76; 95% CI = 1.07-2.88; p = 0.024).

CONCLUSION: Our result suggests that this polymorphism may contribute to the development of T2DM in the MENA Region. This result needs to be confirmed by future well-designed studies with larger sample sizes in diverse populations and ethnicities.

Copyright © 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Keywords: ACE gene; I/D alleles; MENA Region; Meta-analysis; Type 2 diabetes mellitus

Conflict of interest statement

Declaration of competing interest The authors declare that there is no conflict of interests regarding the publication of this paper.

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