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Hermann M, Laxar D, Krall C, et al. Duration of invasive mechanical ventilation prior to extracorporeal membrane oxygenation is not associated with survival in acute respiratory distress syndrome caused by coronavirus disease 2019. Ann Intensive Care. 2022;12(1):6doi: 10.1186/s13613-022-00980-3.
Hermann, M., Laxar, D., Krall, C., Hafner, C., Herzog, O., Kimberger, O., Koenig, S., Kraft, F., Maleczek, M., Markstaller, K., Robak, O., Rössler, B., Schaden, E., Schellongowski, P., Schneeweiss-Gleixner, M., Staudinger, T., Ullrich, R., Wiegele, M., Willschke, H., Zauner, C., & Hermann, A. (2022). Duration of invasive mechanical ventilation prior to extracorporeal membrane oxygenation is not associated with survival in acute respiratory distress syndrome caused by coronavirus disease 2019. Annals of intensive care, 12(1), 6. https://doi.org/10.1186/s13613-022-00980-3
Hermann, Martina, et al. "Duration of invasive mechanical ventilation prior to extracorporeal membrane oxygenation is not associated with survival in acute respiratory distress syndrome caused by coronavirus disease 2019." Annals of intensive care vol. 12,1 (2022): 6. doi: https://doi.org/10.1186/s13613-022-00980-3
Hermann M, Laxar D, Krall C, Hafner C, Herzog O, Kimberger O, Koenig S, Kraft F, Maleczek M, Markstaller K, Robak O, Rössler B, Schaden E, Schellongowski P, Schneeweiss-Gleixner M, Staudinger T, Ullrich R, Wiegele M, Willschke H, Zauner C, Hermann A. Duration of invasive mechanical ventilation prior to extracorporeal membrane oxygenation is not associated with survival in acute respiratory distress syndrome caused by coronavirus disease 2019. Ann Intensive Care. 2022 Jan 13;12(1):6. doi: 10.1186/s13613-022-00980-3. PMID: 35024972; PMCID: PMC8755897.
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Ann Intensive Care. 2022 Jan 13;12(1):6. doi: 10.1186/s13613-022-00980-3.

Duration of invasive mechanical ventilation prior to extracorporeal membrane oxygenation is not associated with survival in acute respiratory distress syndrome caused by coronavirus disease 2019.

Annals of intensive care

Martina Hermann, Daniel Laxar, Christoph Krall, Christina Hafner, Oliver Herzog, Oliver Kimberger, Sebastian Koenig, Felix Kraft, Mathias Maleczek, Klaus Markstaller, Oliver Robak, Bernhard Rössler, Eva Schaden, Peter Schellongowski, Mathias Schneeweiss-Gleixner, Thomas Staudinger, Roman Ullrich, Marion Wiegele, Harald Willschke, Christian Zauner, Alexander Hermann

Affiliations

  1. Department of Anaesthesia, Intensive Care Medicine and Pain Medicine, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
  2. Ludwig Boltzmann Institute for Digital Health and Patient Safety, Spitalgasse 23, BT86, 1090, Vienna, Austria.
  3. Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Spitalgasse 23, BT88, 1090, Vienna, Austria.
  4. Department of Medicine I, Medical University of Vienna, Intensive Care Unit 13i2, Waehringer Guertel 18-20, 1090, Vienna, Austria.
  5. Department of Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
  6. Department of Medicine I, Medical University of Vienna, Intensive Care Unit 13i2, Waehringer Guertel 18-20, 1090, Vienna, Austria. [email protected].

PMID: 35024972 PMCID: PMC8755897 DOI: 10.1186/s13613-022-00980-3

Abstract

BACKGROUND: Duration of invasive mechanical ventilation (IMV) prior to extracorporeal membrane oxygenation (ECMO) affects outcome in acute respiratory distress syndrome (ARDS). In coronavirus disease 2019 (COVID-19) related ARDS, the role of pre-ECMO IMV duration is unclear. This single-centre, retrospective study included critically ill adults treated with ECMO due to severe COVID-19-related ARDS between 01/2020 and 05/2021. The primary objective was to determine whether duration of IMV prior to ECMO cannulation influenced ICU mortality.

RESULTS: During the study period, 101 patients (mean age 56 [SD ± 10] years; 70 [69%] men; median RESP score 2 [IQR 1-4]) were treated with ECMO for COVID-19. Sixty patients (59%) survived to ICU discharge. Median ICU length of stay was 31 [IQR 20.7-51] days, median ECMO duration was 16.4 [IQR 8.7-27.7] days, and median time from intubation to ECMO start was 7.7 [IQR 3.6-12.5] days. Fifty-three (52%) patients had a pre-ECMO IMV duration of > 7 days. Pre-ECMO IMV duration had no effect on survival (p = 0.95). No significant difference in survival was found when patients with a pre-ECMO IMV duration of < 7 days (< 10 days) were compared to ≥ 7 days (≥ 10 days) (p = 0.59 and p = 1.0).

CONCLUSIONS: The role of prolonged pre-ECMO IMV duration as a contraindication for ECMO in patients with COVID-19-related ARDS should be scrutinised. Evaluation for ECMO should be assessed on an individual and patient-centred basis.

© 2022. The Author(s).

Keywords: Acute respiratory distress syndrome; COVID-19; Extracorporeal membrane oxygenation; Invasive mechanical ventilation

References

  1. Intensive Care Med. 2013 Oct;39(10):1704-13 - PubMed
  2. Am J Respir Crit Care Med. 2021 Oct 15;204(8):991-994 - PubMed
  3. N Engl J Med. 2018 May 24;378(21):1965-1975 - PubMed
  4. Intensive Care Med. 2021 Jan;47(1):107-109 - PubMed
  5. J Cardiothorac Vasc Anesth. 2020 Jul;34(7):1720-1722 - PubMed
  6. Ann Intensive Care. 2021 Feb 18;11(1):36 - PubMed
  7. Nature. 2020 Aug;584(7821):430-436 - PubMed
  8. Am J Respir Crit Care Med. 2021 Jul 1;204(1):34-43 - PubMed
  9. Intensive Care Med. 2021 Feb;47(2):208-221 - PubMed
  10. ASAIO J. 2020 Jul;66(7):707-721 - PubMed
  11. ASAIO J. 2021 Jun 1;67(6):601-610 - PubMed
  12. ASAIO J. 2017 Sep/Oct;63(5):650-658 - PubMed
  13. Ann Intensive Care. 2021 Nov 15;11(1):157 - PubMed
  14. Membranes (Basel). 2021 Apr 21;11(5): - PubMed
  15. JAMA. 2020 Apr 28;323(16):1574-1581 - PubMed
  16. Lancet Respir Med. 2021 Aug;9(8):851-862 - PubMed
  17. Lancet Respir Med. 2020 May;8(5):433-434 - PubMed
  18. Lancet Respir Med. 2021 May;9(5):487-497 - PubMed
  19. ASAIO J. 2020 May;66(5):472-474 - PubMed
  20. Am J Respir Crit Care Med. 2019 Oct 15;200(8):1002-1012 - PubMed
  21. Ann Surg. 2004 Oct;240(4):595-605; discussion 605-7 - PubMed
  22. Am J Respir Crit Care Med. 2014 Jun 1;189(11):1374-82 - PubMed
  23. Lancet. 2020 Oct 10;396(10257):1071-1078 - PubMed
  24. Intensive Care Med. 2021 Jan;47(1):60-73 - PubMed
  25. Ann Intensive Care. 2020 Nov 23;10(1):158 - PubMed
  26. JAMA. 2020 Aug 11;324(6):603-605 - PubMed
  27. Intensive Care Med. 2009 Dec;35(12):2105-14 - PubMed
  28. Crit Care. 2021 Jun 14;25(1):211 - PubMed
  29. Wien Klin Wochenschr. 2020 Nov;132(21-22):671-676 - PubMed
  30. Physiol Rep. 2021 Feb;9(3):e14715 - PubMed
  31. Lancet Respir Med. 2020 Nov;8(11):1121-1131 - PubMed
  32. Lancet. 2021 Oct 2;398(10307):1230-1238 - PubMed
  33. Anaesthesia. 2020 Aug;75(8):997-1001 - PubMed

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