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Senís E, Esgleas M, Najas S, et al. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Front Cell Dev Biol. 2021;9:747667doi: 10.3389/fcell.2021.747667.
Senís, E., Esgleas, M., Najas, S., Jiménez-Sábado, V., Bertani, C., Giménez-Alejandre, M., Escriche, A., Ruiz-Orera, J., Hergueta-Redondo, M., Jiménez, M., Giralt, A., Nuciforo, P., Albà, M. M., Peinado, H., Del Toro, D., Hove-Madsen, L., Götz, M., & Abad, M. (2021). TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Frontiers in cell and developmental biology, 9747667. https://doi.org/10.3389/fcell.2021.747667
Senís, Elena, et al. "TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics." Frontiers in cell and developmental biology vol. 9 (2021): 747667. doi: https://doi.org/10.3389/fcell.2021.747667
Senís E, Esgleas M, Najas S, Jiménez-Sábado V, Bertani C, Giménez-Alejandre M, Escriche A, Ruiz-Orera J, Hergueta-Redondo M, Jiménez M, Giralt A, Nuciforo P, Albà MM, Peinado H, Del Toro D, Hove-Madsen L, Götz M, Abad M. TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics. Front Cell Dev Biol. 2021 Dec 31;9:747667. doi: 10.3389/fcell.2021.747667. eCollection 2021. PMID: 35036403; PMCID: PMC8758570.
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Front Cell Dev Biol. 2021 Dec 31;9:747667. doi: 10.3389/fcell.2021.747667. eCollection 2021.

TUNAR lncRNA Encodes a Microprotein that Regulates Neural Differentiation and Neurite Formation by Modulating Calcium Dynamics.

Frontiers in cell and developmental biology

Elena Senís, Miriam Esgleas, Sonia Najas, Verónica Jiménez-Sábado, Camilla Bertani, Marta Giménez-Alejandre, Alba Escriche, Jorge Ruiz-Orera, Marta Hergueta-Redondo, Mireia Jiménez, Albert Giralt, Paolo Nuciforo, M Mar Albà, Héctor Peinado, Daniel Del Toro, Leif Hove-Madsen, Magdalena Götz, María Abad

Affiliations

  1. Cellular Plasticity and Cancer Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
  2. Physiological Genomics, Biomedical Center (BMC), Helmholtz Center Munich, Institute of Stem Cell Research, Großhaderner Str, SyNergy Excellence Cluster, Ludwig-Maximilians-Universitaet (LMU), Munich, Germany.
  3. Instituto de Investigación Biomédica Barcelona (IIBB-CSIC), Instituto de Investigación Biomédica Sant Pau (IIB-Sant Pau) and CIBERCV, Barcelona, Spain.
  4. Cardiovascular and Metabolic Sciences, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
  5. Microenvironment and Metastasis Laboratory, Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain.
  6. Department of Biological Sciences, Institute of Neurosciences, IDIBAPS, CIBERNED, University of Barcelona, Barcelona, Spain.
  7. Molecular Oncology Group, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
  8. Evolutionary Genomics Group, Research Programme on Biomedical Informatics, Hospital del Mar Medical Research Institute (IMIM) and Universitat Pompeu Fabra (UPF), Barcelona, Spain.
  9. Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.

PMID: 35036403 PMCID: PMC8758570 DOI: 10.3389/fcell.2021.747667

Abstract

Long noncoding RNAs (lncRNAs) are regulatory molecules which have been traditionally considered as "non-coding". Strikingly, recent evidence has demonstrated that many non-coding regions, including lncRNAs, do in fact contain small-open reading frames that code for small proteins that have been called microproteins. Only a few of them have been characterized so far, but they display key functions in a wide variety of cellular processes. Here, we show that TUNAR lncRNA encodes an evolutionarily conserved microprotein expressed in the nervous system that we have named pTUNAR. pTUNAR deficiency in mouse embryonic stem cells improves their differentiation potential towards neural lineage both

Copyright © 2021 Senís, Esgleas, Najas, Jiménez-Sábado, Bertani, Giménez-Alejandre, Escriche, Ruiz-Orera, Hergueta-Redondo, Jiménez, Giralt, Nuciforo, Albà, Peinado, Toro, Hove-Madsen, Götz and Abad.

Keywords: TUNAR; calcium; long non-coding RNAs; micropeptides; microproteins; neural differentiation; neurite formation; sORF encoded peptides

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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