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Thi Chung Duong T, Nguyen THN, Thi Ngoc Nguyen T, et al. Diagnostic and prognostic value of miR-200 family in breast cancer: A meta-analysis and systematic review. Cancer Epidemiol. 2022;77:102097doi: 10.1016/j.canep.2022.102097.
Thi Chung Duong, T., Nguyen, T. H. N., Thi Ngoc Nguyen, T., Huynh, L. H., Ngo, H. P., & Thi Nguyen, H. (2022). Diagnostic and prognostic value of miR-200 family in breast cancer: A meta-analysis and systematic review. Cancer epidemiology, 77102097. https://doi.org/10.1016/j.canep.2022.102097
Thi Chung Duong, Thuy, et al. "Diagnostic and prognostic value of miR-200 family in breast cancer: A meta-analysis and systematic review." Cancer epidemiology vol. 77 (2022): 102097. doi: https://doi.org/10.1016/j.canep.2022.102097
Thi Chung Duong T, Nguyen THN, Thi Ngoc Nguyen T, Huynh LH, Ngo HP, Thi Nguyen H. Diagnostic and prognostic value of miR-200 family in breast cancer: A meta-analysis and systematic review. Cancer Epidemiol. 2022 Jan 11;77:102097. doi: 10.1016/j.canep.2022.102097. Epub 2022 Jan 11. PMID: 35030348.
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Cancer Epidemiol. 2022 Jan 11;77:102097. doi: 10.1016/j.canep.2022.102097. Epub 2022 Jan 11.

Diagnostic and prognostic value of miR-200 family in breast cancer: A meta-analysis and systematic review.

Cancer epidemiology

Thuy Thi Chung Duong, Thu Huynh Ngoc Nguyen, Thanh Thi Ngoc Nguyen, Luan Huu Huynh, Hoang Phan Ngo, Hue Thi Nguyen

Affiliations

  1. Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City, Viet Nam.
  2. Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City, Viet Nam. Electronic address: [email protected].

PMID: 35030348 DOI: 10.1016/j.canep.2022.102097

Abstract

BACKGROUND: Breast cancer (BC) is the most common cancer for women all over the world. Great interests have been paid to discover accurate and noninvasive methods for breast cancer diagnosis and prognosis. Although the diagnostic and prognostic value of microRNA-200 (miRNA- 200, miR-200) family has been revealed in many studies, the results were inconsistent. Thus, this meta-analysis aims to assess the overall value of miRNA-200 family in breast cancer diagnosis and prognosis.

METHOD: Relevant studies were searched from the following databases: PubMed, PMC, EMBASE, and ScienceDirect using key words: "miRNA-200 family" or "miR-141″ or "miR-200a" or "miR-200b" or "miR-200c" or "miR-429″ and "breast cancers" or "breast carcinoma" or "breast malignance" or "breast tumor". This meta-analysis was conducted with 16 articles comprising in 9190 cases and 456 control. The sensitivity, specificity, AUC were then calculated to estimate the diagnostic accuracy of using miR-200 family. As for the prognostic value of miR-200 family, the pooled hazard ratio (HR) was assessed. Heterogeneity among individual studies was also examined by subgroup analyses.

RESULT: A total of 16 articles were included in the meta-analysis. The pooled sensitivity was 0.86 (95% CI: 0.83-0.89); the pooled specificity was 0.83 (95% CI: 0.73-0.90); the pooled +LR was 4.958 (95%CI: 3.028-8.117); the pooled -LR was 0.170 (95%CI: 0.135-0.213); the pooled DOR was 29.227 (95%CI: 15.415-55.417); the pooled AUC was 0.927 (95% CI: 0.914-0.939). The meta-analysis then revealed that high expression of miR-200 family was corresponded to poor OS (HR: 2.07, 95% CI: 1.30-3.25), poor PFS (HR: 1.52, 95% CI: 1.08-2.09), poor RFS (HR: 2.14, 95% CI: 1.05-4.56), and poor DFS (HR: 2.00, 95% CI: 0.91-2.97).

CONCLUSION: The MiR-200 family has high diagnostic accuracy and can be used as an important biomarker to prognosticate breast cancer.

Copyright © 2022 Elsevier Ltd. All rights reserved.

Keywords: Breast cancer; Diagnosis; Meta-analysis; MiR-200 family; Prognosis

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