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Photodiagnosis Photodyn Ther. 2021 Dec 13;37:102683. doi: 10.1016/j.pdpdt.2021.102683. Epub 2021 Dec 13.

Carbon nitride nanomaterials with application in photothermal and photodynamic therapies.

Photodiagnosis and photodynamic therapy

Gabriela N Bosio, Daniel O Mártire

Affiliations

  1. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de la Plata, CONICET, Casilla de Correo 16, Sucursal 4, La Plata 1900, Argentina. Electronic address: [email protected].
  2. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas (INIFTA), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de la Plata, CONICET, Casilla de Correo 16, Sucursal 4, La Plata 1900, Argentina. Electronic address: [email protected].

PMID: 34915184 DOI: 10.1016/j.pdpdt.2021.102683

Abstract

Phototherapies offer treatment of tumors with high spatial selectivity. Photodynamic therapy (PDT) consists in the administration of a photosensitizer (PS) followed by local photoirradiation with light of specific wavelength. The excited states of the PS interact with biomolecules and molecular oxygen producing reactive oxygen species (ROS), which initiate cell death. Photothermal therapy (PTT) employs photothermal agents to harvest the energy from light and convert it into heat to produce a temperature increase of the surrounding environment leading to cell death. Due to their good biocompatibility and unique photophysical properties, carbon-based materials are suitable for application in PDT and PTT. In particular, graphitic carbon nitride (g-C

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Hypoxia; Photodynamic therapy; Photothermal therapy; Theranostics; g-C(3)N(4)

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