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Mennati A, Rostamizadeh K, Manjili HK, et al. Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line. Int J Biol Macromol. 2022;200:335-349doi: 10.1016/j.ijbiomac.2021.12.197.
Mennati, A., Rostamizadeh, K., Manjili, H. K., Fathi, M., & Danafar, H. (2022). Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line. International journal of biological macromolecules, 200335-349. https://doi.org/10.1016/j.ijbiomac.2021.12.197
Mennati, Afsaneh, et al. "Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line." International journal of biological macromolecules vol. 200 (2022): 335-349. doi: https://doi.org/10.1016/j.ijbiomac.2021.12.197
Mennati A, Rostamizadeh K, Manjili HK, Fathi M, Danafar H. Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line. Int J Biol Macromol. 2022 Jan 06;200:335-349. doi: 10.1016/j.ijbiomac.2021.12.197. Epub 2022 Jan 06. PMID: 34999039.
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Int J Biol Macromol. 2022 Jan 06;200:335-349. doi: 10.1016/j.ijbiomac.2021.12.197. Epub 2022 Jan 06.

Co-delivery of siRNA and lycopene encapsulated hybrid lipid nanoparticles for dual silencing of insulin-like growth factor 1 receptor in MCF-7 breast cancer cell line.

International journal of biological macromolecules

Afsaneh Mennati, Kobra Rostamizadeh, Hamidreza Kheiri Manjili, Mojtaba Fathi, Hossein Danafar

Affiliations

  1. Zanjan Pharmaceutical Nanotechnology Research Center, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran; Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
  2. Zanjan Pharmaceutical Nanotechnology Research Center, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
  3. Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
  4. Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Biochemistry and Genetics, Qazvin University of Medical Sciences, Qazvin, Iran. Electronic address: [email protected].
  5. Zanjan Pharmaceutical Nanotechnology Research Center, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran; Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Electronic address: [email protected].

PMID: 34999039 DOI: 10.1016/j.ijbiomac.2021.12.197

Abstract

Insulin-like growth factor-1 receptor (IGF-1R) is expressed in malignant and normal breast tissue, and its intermittent activation by multiple IGF-1 signaling pathways leads to neoplasm cell proliferation, impaired apoptosis, increased survival, and resistance to cytotoxic therapeutic agents. Therefore, simultaneous suppression of the receptor and its cognate ligand would be a powerful promising strategy inhibiting malignant phenotypes of breast cancer cells. In the present study, Methoxypoly(ethylene glycol) - Poly(caprolactone) was hybridized with Dimethyldioctadecylammonium bromide (DDAB) cationic lipid (mPEG-PCL-DDAB) nanoparticles (NPs) and used as a carrier for simultaneous delivery of lycopene and insulin-like growth factor 1 receptor-specific lycopene encapsulated-mPEG-PCL-DDAB nanoparticle/siRNA to MCF-7 breast cancer cells. Then, the antitumor effects of this construct were evaluated in vitro. The results demonstrated that the synthesized mPEG-PCL-DDAB nanoparticle had suitable physicochemical properties. The use of mPEG-PCL-DDAB nanoparticle-loaded anti-insulin-like growth factor 1 receptor-siRNA and lycopene dramatically induced the process of apoptosis and arrested cell cycle in the MCF-7 tumor cell lines. In general, the findings of this study demonstrated the potency of mPEG-PCL-DDAB nanoparticles for dual delivery of siRNA, and lycopene in breast cancer cell lines followed the induction of apoptosis.

Copyright © 2021. Published by Elsevier B.V.

Keywords: Insulin-like growth factor 1 receptor; Lycopene; Methoxypoly(ethylene glycol); Nanoparticle; Poly(caprolactone); siRNA

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