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Zhang X, Monnoye M, Mariadassou M, et al. Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice. Front Immunol. 2021;12:742584doi: 10.3389/fimmu.2021.742584.
Zhang, X., Monnoye, M., Mariadassou, M., Beguet-Crespel, F., Lapaque, N., Heberden, C., & Douard, V. (2021). Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice. Frontiers in immunology, 12742584. https://doi.org/10.3389/fimmu.2021.742584
Zhang, Xufei, et al. "Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice." Frontiers in immunology vol. 12 (2021): 742584. doi: https://doi.org/10.3389/fimmu.2021.742584
Zhang X, Monnoye M, Mariadassou M, Beguet-Crespel F, Lapaque N, Heberden C, Douard V. Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice. Front Immunol. 2021 Dec 27;12:742584. doi: 10.3389/fimmu.2021.742584. eCollection 2021. PMID: 35024040; PMCID: PMC8744209.
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Front Immunol. 2021 Dec 27;12:742584. doi: 10.3389/fimmu.2021.742584. eCollection 2021.

Glucose but Not Fructose Alters the Intestinal Paracellular Permeability in Association With Gut Inflammation and Dysbiosis in Mice.

Frontiers in immunology

Xufei Zhang, Magali Monnoye, Mahendra Mariadassou, Fabienne Beguet-Crespel, Nicolas Lapaque, Christine Heberden, Veronique Douard

Affiliations

  1. Université Paris-Saclay, INRAE, AgroParisTech, MICALIS Institute, Jouy-en-Josas, France.
  2. Université Paris Saclay, INRAE, MaIAGE, Jouy-en-Josas, France.

PMID: 35024040 PMCID: PMC8744209 DOI: 10.3389/fimmu.2021.742584

Abstract

A causal correlation between the metabolic disorders associated with sugar intake and disruption of the gastrointestinal (GI) homeostasis has been suggested, but the underlying mechanisms remain unclear. To unravel these mechanisms, we investigated the effect of physiological amounts of fructose and glucose on barrier functions and inflammatory status in various regions of the GI tract and on the cecal microbiota composition. C57BL/6 mice were fed chow diet and given 15% glucose or 15% fructose in drinking water for 9 weeks. We monitored caloric intake, body weight, glucose intolerance, and adiposity. The intestinal paracellular permeability, cytokine, and tight junction protein expression were assessed in the jejunum, cecum, and colon. In the cecum, the microbiota composition was determined. Glucose-fed mice developed a marked increase in total adiposity, glucose intolerance, and paracellular permeability in the jejunum and cecum while fructose absorption did not affect any of these parameters. Fructose-fed mice displayed increased circulation levels of IL6. In the cecum, both glucose and fructose intake were associated with an increase in

Copyright © 2021 Zhang, Monnoye, Mariadassou, Beguet-Crespel, Lapaque, Heberden and Douard.

Keywords: Caco-2; Desulfovibrio; fructose; glucose; paracellular permeability; pro-inflammatory cytokines

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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