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Chen X, Wu J, Cao X, et al. The role of gel wound dressings loaded with stem cells in the treatment of diabetic foot ulcers. Am J Transl Res. 2021;13(12):13261-13272
Chen, X., Wu, J., Cao, X., Jiang, H., Wu, Z., Zeng, Z., Chen, H., & Zhang, J. (2021). The role of gel wound dressings loaded with stem cells in the treatment of diabetic foot ulcers. American journal of translational research, 13(12), 13261-13272.
Chen, Xionglin, et al. "The role of gel wound dressings loaded with stem cells in the treatment of diabetic foot ulcers." American journal of translational research vol. 13,12 (2021): 13261-13272.
Chen X, Wu J, Cao X, Jiang H, Wu Z, Zeng Z, Chen H, Zhang J. The role of gel wound dressings loaded with stem cells in the treatment of diabetic foot ulcers. Am J Transl Res. 2021 Dec 15;13(12):13261-13272. eCollection 2021. PMID: 35035674; PMCID: PMC8748097.
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Am J Transl Res. 2021 Dec 15;13(12):13261-13272. eCollection 2021.

The role of gel wound dressings loaded with stem cells in the treatment of diabetic foot ulcers.

American journal of translational research

Xionglin Chen, Jianfang Wu, Xiaoming Cao, He Jiang, Zhiren Wu, Zidu Zeng, Hui Chen, Jie Zhang

Affiliations

  1. Department of Histology & Embryology and Medical Genetics, School of Medicine, Jiujiang University Jiujiang 332000, Jiangxi, China.
  2. Department of Pathogenic Biology and Immunology, School of Medicine, Jiujiang University Jiujiang 332000, Jiangxi, China.
  3. Department of Anatomy, School of Medicine, Jiujiang University Jiujiang 332000, Jiangxi, China.
  4. Department of Preventive Medicine, Grade 2019, School of Medicine, Jiujiang University Jiujiang 332000, Jiangxi, China.

PMID: 35035674 PMCID: PMC8748097

Abstract

Diabetic foot ulcers (DFUs) are a serious complication of diabetes and the main cause of nontraumatic lower limb amputations, resulting in a serious economic burden on society. The main causes of DFUs include peripheral neuropathy, foot deformity, chronic inflammation, and peripheral artery disease. There are many clinical approaches for the treatment of DFUs, but they are all aimed at addressing a single aetiological factor. Stem cells (SCs), which express many cytokines and a variety of nerve growth factors and modulate immunological function in the wound, may accelerate DFU healing by promoting angiogenesis, cell proliferation, and nerve growth and regulating the inflammatory response. However, the survival time of SCs without scaffold support in the wound is short. Multifunctional gel wound dressings play a critical role in skin wound healing due to their ability to maintain SC survival for a long time, provide moisture and prevent electrolyte and water loss in DFUs. Among the many methods for clinical treatment of DFUs, the most successful one is therapy with gel dressings loaded with SCs. To accelerate DFU healing, gel wound dressings loaded with SCs are needed to promote the survival and migration of SCs and increase wound contraction. This review summarizes the research advancements regarding multifunctional gel wound dressings and SCs in the treatment of DFU to demonstrate the effectiveness and safety of this combinational therapeutic strategy.

AJTR Copyright © 2021.

Keywords: Diabetic foot ulcers; gels; stem cell; wound dressing

Conflict of interest statement

None.

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