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Wallace MJ, Jean S, Wallace MA, et al. Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction. mBio. 2022;e0360321doi: 10.1128/mbio.03603-21.
Wallace, M. J., Jean, S., Wallace, M. A., Burnham, C. D., & Dantas, G. (2022). Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction. mBio, e0360321. https://doi.org/10.1128/mbio.03603-21
Wallace, Miranda J, et al. "Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction." mBio vol. (2022): e0360321. doi: https://doi.org/10.1128/mbio.03603-21
Wallace MJ, Jean S, Wallace MA, Burnham CD, Dantas G. Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction. mBio. 2022 Jan 18;e0360321. doi: 10.1128/mbio.03603-21. Epub 2022 Jan 18. PMID: 35038926.
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mBio. 2022 Jan 18;e0360321. doi: 10.1128/mbio.03603-21. Epub 2022 Jan 18.

Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction.

mBio

Miranda J Wallace, Sophonie Jean, Meghan A Wallace, Carey-Ann D Burnham, Gautam Dantas

Affiliations

  1. Department of Pathology & Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  2. The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, USA.
  3. Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
  4. Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  5. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
  6. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  7. Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.

PMID: 35038926 DOI: 10.1128/mbio.03603-21

Abstract

Bacteroides fragilis group (BFG) are the most frequently recovered anaerobic bacteria from human infections, and resistance to frontline antibiotics is emerging. In the absence of routine antimicrobial susceptibility testing (AST) for BFG in most clinical settings, we assessed the utility of clinical and modern genomics tools to determine BFG species-level identification and resistance patterns. A total of 174 BFG clinical isolates supplemented with 20 archived carbapenem-resistant B. fragilis

Keywords: Bacteroides; anaerobes; antibiotic resistance; beta-lactams; carbapenems; genomics; mass spectrometry; taxonomy

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