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Turgut E, Yildirim M, Sakcak B, et al. Predicting miscarriage using systemic immune-inflammation index. J Obstet Gynaecol Res. 2022;doi: 10.1111/jog.15156.
Turgut, E., Yildirim, M., Sakcak, B., Ayhan, S. G., Tekin, O. M., & Sahin, D. (2022). Predicting miscarriage using systemic immune-inflammation index. The journal of obstetrics and gynaecology research, . https://doi.org/10.1111/jog.15156
Turgut, Ezgi, et al. "Predicting miscarriage using systemic immune-inflammation index." The journal of obstetrics and gynaecology research vol. (2022). doi: https://doi.org/10.1111/jog.15156
Turgut E, Yildirim M, Sakcak B, Ayhan SG, Tekin OM, Sahin D. Predicting miscarriage using systemic immune-inflammation index. J Obstet Gynaecol Res. 2022 Jan 17; doi: 10.1111/jog.15156. Epub 2022 Jan 17. PMID: 35040233.
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J Obstet Gynaecol Res. 2022 Jan 17; doi: 10.1111/jog.15156. Epub 2022 Jan 17.

Predicting miscarriage using systemic immune-inflammation index.

The journal of obstetrics and gynaecology research

Ezgi Turgut, Muradiye Yildirim, Bedri Sakcak, Sule G Ayhan, Ozlem M Tekin, Dilek Sahin

Affiliations

  1. Department of Obstetrics and Gynecology, Ministry of Health, Ankara City Hospital, Ankara, Turkey.

PMID: 35040233 DOI: 10.1111/jog.15156

Abstract

AIM: To evaluate the clinical significance of the systemic immune-inflammation index (SII) for patients who had miscarriages.

MATERIALS: The retrospective study included 709 pregnant women who had a miscarriage (nonviable intrauterine pregnancy up to 20 weeks of gestation) and 676 women who carried a viable intrauterine pregnancy up to 20 weeks of gestation-serving as the control group. The study and the control group were compared in terms of demographic characteristics, laboratory test results, and SII values. Furthermore, laboratory test results and SII values were compared between patients in the study group and the control group with a history of genital bleeding (threatened abortion).

RESULTS: The mean gestational week of pregnancy was 9.5 ± 3 for the control group and 8.3 ± 2.5 for the study group (p = 0.150). The SII values were higher in the study group than in the control group (p = 0.030). In all participants with a clinical history of genital bleeding, the leukocyte count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR), and SII values were higher in the miscarriage group than the group with viable fetus (p = 0.031, p = 0.003, p = 0.002, p < 0.001). Based on a receiver operating characteristic (ROC) curve analysis, the SII cutoff value for miscarriage was 883.95 (10

CONCLUSION: High SII values in early pregnancy may be used as an additional marker for the prediction of miscarriage, in pregnant women with threatened abortion. Further prediction models including maternal risk factors and multiple markers may be more valuable for clinical practice.

© 2022 Japan Society of Obstetrics and Gynecology.

Keywords: miscarriage; neutrophil-to-lymphocyte ratio; systemic immune-inflammation index; threatened abortion

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