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Wingerchuk DM, Weinshenker BG. The natural history of multiple sclerosis: implications for trial design. Curr Opin Neurol. 1999;12(3):345-9doi: 10.1097/00019052-199906000-00013.
Wingerchuk, D. M., & Weinshenker, B. G. (1999). The natural history of multiple sclerosis: implications for trial design. Current opinion in neurology, 12(3), 345-9. https://doi.org/10.1097/00019052-199906000-00013
Wingerchuk, D M, and Weinshenker, B G. "The natural history of multiple sclerosis: implications for trial design." Current opinion in neurology vol. 12,3 (1999): 345-9. doi: https://doi.org/10.1097/00019052-199906000-00013
Wingerchuk DM, Weinshenker BG. The natural history of multiple sclerosis: implications for trial design. Curr Opin Neurol. 1999 Jun;12(3):345-9. doi: 10.1097/00019052-199906000-00013. PMID: 10499179.
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Curr Opin Neurol. 1999 Jun;12(3):345-9. doi: 10.1097/00019052-199906000-00013.

The natural history of multiple sclerosis: implications for trial design.

Current opinion in neurology

D M Wingerchuk, B G Weinshenker

Affiliations

  1. Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

PMID: 10499179 DOI: 10.1097/00019052-199906000-00013

Abstract

The understanding of the natural history of multiple sclerosis has many implications for the design and interpretation of randomized controlled trials. Selection criteria, patient stratification, outcome measurements, and definitions of treatment failure can influence randomized controlled trial results and limit comparisons among trials. The focus of future studies should shift from short-term determinations of efficacy to definitive evaluations of long-term effectiveness. This will require novel investigative strategies such as the use of historic controls derived from natural history studies.

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