Display options
Cite
Gundling F, Wittenburg H, Tannapfel A, et al. Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report. J Med Case Rep. 2008;2:191doi: 10.1186/1752-1947-2-191.
Gundling, F., Wittenburg, H., Tannapfel, A., & Mossner, J. (2008). Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report. Journal of medical case reports, 2191. https://doi.org/10.1186/1752-1947-2-191
Gundling, Felix, et al. "Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report." Journal of medical case reports vol. 2 (2008): 191. doi: https://doi.org/10.1186/1752-1947-2-191
Gundling F, Wittenburg H, Tannapfel A, Mossner J. Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report. J Med Case Rep. 2008 Jun 03;2:191. doi: 10.1186/1752-1947-2-191. PMID: 18522718; PMCID: PMC2443157.
Copy Download .nbib Format: NLM
Share it on

J Med Case Rep. 2008 Jun 03;2:191. doi: 10.1186/1752-1947-2-191.

Neurological presentation of Whipple's disease after long-term antibiotic treatment: a case report.

Journal of medical case reports

Felix Gundling, Henning Wittenburg, Andrea Tannapfel, Joachim Mossner

Affiliations

  1. Second Department of Medicine, Bogenhausen Hospital, Academic Teaching Hospital, Technical University of Munich, Munich, Germany. [email protected]

PMID: 18522718 PMCID: PMC2443157 DOI: 10.1186/1752-1947-2-191

Abstract

INTRODUCTION: Whipple's disease is a rare systemic infectious disorder caused by Tropheryma whipplei.

CASE PRESENTATION: We report a 68-year-old male with Whipple's disease of the central nervous system following long-term antibiotic therapy and many years after the initial clinical onset.

CONCLUSION: The combination of trimethoprim and sulphamethoxazole does not prevent or cure involvement of the central nervous system in all patients with Whipple's disease. If relapse of the central nervous system occurs treatment with meropenem might be a useful alternative.

References

  1. Gastroenterology. 1996 Jun;110(6):1735-43 - PubMed
  2. J Neurol Neurosurg Psychiatry. 2000 Jan;68(1):2-5 - PubMed
  3. Ital J Neurol Sci. 1998 Apr;19(2):101-5 - PubMed
  4. Gastroenterology. 1997 Aug;113(2):434-41 - PubMed
  5. J Immunol. 2006 Aug 1;177(3):2015-22 - PubMed
  6. QJM. 2006 Sep;99(9):609-23 - PubMed
  7. Gut. 1993 Nov;34(11):1627-9 - PubMed
  8. J Infect Dis. 2003 Sep 15;188(6):797-800 - PubMed
  9. Am J Gastroenterol. 2005 May;100(5):1167-73 - PubMed
  10. Ann Intern Med. 1990 Mar 15;112(6):467-9 - PubMed
  11. Clin Microbiol Rev. 2001 Jul;14(3):561-83 - PubMed
  12. Lancet. 2003 Jan 18;361(9353):239-46 - PubMed
  13. Ann Intern Med. 1998 Dec 1;129(11):875-7 - PubMed
  14. Medicine (Baltimore). 2002 Nov;81(6):443-57 - PubMed
  15. Z Gastroenterol. 2001 Apr;39(4):305-9 - PubMed

Publication Types