Display options
Cite
Determinants of survival in patients with malignant ventricular arrhythmia associated with coronary artery disease. Am J Cardiol. 1988;61(10):791-7doi: 10.1016/0002-9149(88)91068-5.
(1988). Determinants of survival in patients with malignant ventricular arrhythmia associated with coronary artery disease. The American journal of cardiology, 61(10), 791-7. https://doi.org/10.1016/0002-9149(88)91068-5
"Determinants of survival in patients with malignant ventricular arrhythmia associated with coronary artery disease." The American journal of cardiology vol. 61,10 (1988): 791-7. doi: https://doi.org/10.1016/0002-9149(88)91068-5
Determinants of survival in patients with malignant ventricular arrhythmia associated with coronary artery disease. Am J Cardiol. 1988 Apr 01;61(10):791-7. doi: 10.1016/0002-9149(88)91068-5. PMID: 3354443.
Copy Download .nbib Format: NLM
Share it on
Full text links
Elsevier Science

Am J Cardiol. 1988 Apr 01;61(10):791-7. doi: 10.1016/0002-9149(88)91068-5.

Determinants of survival in patients with malignant ventricular arrhythmia associated with coronary artery disease.

The American journal of cardiology

[No authors listed]

PMID: 3354443 DOI: 10.1016/0002-9149(88)91068-5

Abstract

The long-term survival data in patients with coronary artery disease and a history of malignant ventricular arrhythmia, defined as noninfarction ventricular fibrillation (VF) or hemodynamically compromising ventricular tachycardia (VT) followed for up to 9 years, were analyzed. In this group of 161 patients there was a total of 57 deaths, of which 35 (63%) were sudden. Life-table analysis demonstrated a 10% sudden death rate for all patients in the first year and a 7% annual rate in the subsequent 4 years. In patients managed noninvasively, the overall mortality rate was 27% over 9 years, or 3% per year. Suppression of ventricular tachycardia on both ambulatory monitoring and exercise testing was associated with improved survival. In patients evaluated by electrophysiologic testing the sudden death rate was 1.4% per year over an average of 5 years. This survival rate was not different compared with the noninvasive group (p = 0.09). Measures of left ventricular dysfunction and the frequency of ventricular arrhythmia before and after drug therapy were associated with a risk of sudden cardiac death by univariate analysis. Multivariate regression analysis identified 4 variables as independent predictors of sudden cardiac death: rales (p = 0.009), the number of runs of VT during exercise testing while receiving antiarrhythmic drug therapy (p = 0.0003), a history of congestive heart failure (p = 0.0009) and the number of premature beats on Holter monitoring (p = 0.01). These findings support the concept that suppression of repetitive arrhythmia on Holter monitor and exercise testing is a marker for improved survival among patients with malignant ventricular arrhythmia.(ABSTRACT TRUNCATED AT 250 WORDS)

Similar articles

LinkOut - more resources