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Christoph K, Beck FX, Neuhofer W. Osmoadaptation of Mammalian cells - an orchestrated network of protective genes. Curr Genomics. 2007;8(4):209-18doi: 10.2174/138920207781386979.
Christoph, K., Beck, F. X., & Neuhofer, W. (2007). Osmoadaptation of Mammalian cells - an orchestrated network of protective genes. Current genomics, 8(4), 209-18. https://doi.org/10.2174/138920207781386979
Christoph, Küper, et al. "Osmoadaptation of Mammalian cells - an orchestrated network of protective genes." Current genomics vol. 8,4 (2007): 209-18. doi: https://doi.org/10.2174/138920207781386979
Christoph K, Beck FX, Neuhofer W. Osmoadaptation of Mammalian cells - an orchestrated network of protective genes. Curr Genomics. 2007 Jun;8(4):209-18. doi: 10.2174/138920207781386979. PMID: 18645598; PMCID: PMC2430686.
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Curr Genomics. 2007 Jun;8(4):209-18. doi: 10.2174/138920207781386979.

Osmoadaptation of Mammalian cells - an orchestrated network of protective genes.

Current genomics

Küper Christoph, Franz-X Beck, Wolfgang Neuhofer

Affiliations

  1. Department of Physiology, University of Munich, Munich, Germany.

PMID: 18645598 PMCID: PMC2430686 DOI: 10.2174/138920207781386979

Abstract

In mammals, the cells of the renal medulla are physiologically exposed to interstitial osmolalities several-fold higher that found in any other tissue. Nevertheless, these cells not only have the ability to survive in this harsh environment, but also to function normally, which is critical for maintenance of systemic electrolyte and fluid homeostasis. Over the last two decades, a substantial body of evidence has accumulated, indicating that sequential and well orchestrated genomic responses are required to provide tolerance to osmotic stress. This includes the enhanced expression and action of immediate-early genes, growth arrest and DNA damage inducible genes (GADDs), genes involved in cell cycle control and apoptosis, heat shock proteins, and ultimately that of genes involved in the intracellular accumulation of nonperturbing organic osmolytes. The present review summarizes the sequence of genomic responses conferring resistance against osmotic stress. In addition, the regulatory mechanisms mediating the coordinated genomic response to osmotic stress will be highlighted.

Keywords: Osmotic stress; gene expression; osmoadaptation; osmoprotective genes; renal medullary cells

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