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Matthews JC, Dardas TF, Dorsch MP, et al. Right-sided heart failure: diagnosis and treatment strategies. Curr Treat Options Cardiovasc Med. 2008;10(4):329-41doi: 10.1007/s11936-008-0053-6.
Matthews, J. C., Dardas, T. F., Dorsch, M. P., & Aaronson, K. D. (2008). Right-sided heart failure: diagnosis and treatment strategies. Current treatment options in cardiovascular medicine, 10(4), 329-41. https://doi.org/10.1007/s11936-008-0053-6
Matthews, Jennifer Cowger, et al. "Right-sided heart failure: diagnosis and treatment strategies." Current treatment options in cardiovascular medicine vol. 10,4 (2008): 329-41. doi: https://doi.org/10.1007/s11936-008-0053-6
Matthews JC, Dardas TF, Dorsch MP, Aaronson KD. Right-sided heart failure: diagnosis and treatment strategies. Curr Treat Options Cardiovasc Med. 2008 Aug;10(4):329-41. doi: 10.1007/s11936-008-0053-6. PMID: 18647588.
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Curr Treat Options Cardiovasc Med. 2008 Aug;10(4):329-41. doi: 10.1007/s11936-008-0053-6.

Right-sided heart failure: diagnosis and treatment strategies.

Current treatment options in cardiovascular medicine

Jennifer Cowger Matthews, Todd F Dardas, Michael P Dorsch, Keith D Aaronson

Affiliations

  1. Department of Internal Medicine, Division of Cardiovascular Medicine, Heart Failure, and Cardiac Transplant, University of Michigan Health System, 1500 East Medical Center Drive, SPC 5853, Ann Arbor, MI 48109, USA. [email protected]

PMID: 18647588 DOI: 10.1007/s11936-008-0053-6

Abstract

Right ventricular (RV) dysfunction in the setting of cardiomyopathy, ischemia, and pulmonary hypertension is associated with high morbidity and mortality, but therapeutic clinical trials examining RV failure as a primary outcome are lacking. This review focuses on the ontologic, morphologic, and microscopic differences between the right and left ventricles. It also discusses the rationale and potential risks associated with the extrapolation of medical therapies used in left ventricular failure and pulmonary arterial hypertension management to the treatment of RV failure. Finally, it introduces the reader to new echocardiographic techniques that may be used to diagnose clinical and subclinical RV systolic and diastolic dysfunction. Given the anticipated rise in the prevalence of RV dysfunction, more studies are needed to gain a better understanding of RV cellular and subcellular function and its response to pathologic stressors and disease so that therapeutic targets can be devised to improve RV failure morbidity and mortality.

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