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Carini M, Maffei Facino R, Aldini G, et al. The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E. Int J Cosmet Sci. 1998;20(4):203-15doi: 10.1046/j.1467-2494.1998.176606.x.
Carini, M., Maffei Facino, R., Aldini, G., Callonii, M. T., Bombardelli, E., & Morazzoni, P. (1998). The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E. International journal of cosmetic science, 20(4), 203-15. https://doi.org/10.1046/j.1467-2494.1998.176606.x
Carini, M, et al. "The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E." International journal of cosmetic science vol. 20,4 (1998): 203-15. doi: https://doi.org/10.1046/j.1467-2494.1998.176606.x
Carini M, Maffei Facino R, Aldini G, Callonii MT, Bombardelli E, Morazzoni P. The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E. Int J Cosmet Sci. 1998 Aug;20(4):203-15. doi: 10.1046/j.1467-2494.1998.176606.x. PMID: 18505504.
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Int J Cosmet Sci. 1998 Aug;20(4):203-15. doi: 10.1046/j.1467-2494.1998.176606.x.

The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E.

International journal of cosmetic science

M Carini, R Maffei Facino, G Aldini, M T Callonii, E Bombardelli, P Morazzoni

Affiliations

  1. Istituto Chimico Farmaceutico Tossicologico, Scuola diSpecializzazione in Scienza e Tecnologia Cosmetiche,University of Milan, Viale Abruzzi, Milan, Italy.

PMID: 18505504 DOI: 10.1046/j.1467-2494.1998.176606.x

Abstract

The protective effect of procyanidins (catechin oligomers) from Vitis vinifera seeds on the UVB-promoted photo-oxygenation of polyunsaturated fatty acids (PUFAs) (linoleic, linolenic and arachidonic acids, 35 mM) has been studied in 0.5 mM sodium dodecylsulfate micelles exposed to UVB radiation (1-8 J cm-2) and determined qualitatively by Fourier transform infrared spectroscopy (FT-IR) and quantitatively by UV spectroscopy (conjugated dienes and total lipid hydroperoxides). Procyanidins (1-10 muM) strongly and dose-dependently inhibit the formation of PUFA hydroperoxides (IC50 = 4-6 muM), with a potency comparable to that of vitamin E. In these micellar systems, a strong co-operative interaction (synergistic effect) between procyanidins and vitamin E (1:1 molar ratio) in PUFA protection was demonstrated; this, as shown by electron spin resonance (ESR) studies, is a result of the ability of procyanidins to regenerate alpha-tocopherol from the alpha-tocopheroxyl radical (generated by a UV Solar Simulator), through a hydrogen transfer mechanism. HPLC monitoring of vitamin E in PUFAs micelles oxidatively stressed by UVB, confirms that procyanidins save vitamin E from consumption. All these findings, if properly extrapolated to an in vivo situation, indicate that this class of radical scavengers can be used as adjuvants of physical/chemical sunscreens in skin protection from photodamage.

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