Exp Clin Cardiol. 2007;12(2):63-6.
Effect of acute subendocardial ischemia on ventricular refractory periods.
Experimental and clinical cardiology
Longle Ma, Lexin Wang
Affiliations
Affiliations
- Department of Cardiology, Liaocheng City People's Hospital, Shandong Province, People's Republic of China.
PMID: 18650984
PMCID: PMC2359600
Abstract
OBJECTIVES: To investigate the impact of acute subendocardial ischemia on the dispersion of ventricular refractory periods.
METHODS: Acute subendocardial ischemia was induced in sheep by partial ligation of the left circumflex coronary artery and rapid pacing of the left atrium. The ventricular effective refractory period (ERP) was measured in five areas of the left ventricle by a programmed premature stimulation technique.
RESULTS: The average ERP and ERP dispersion remained unchanged in the control group (n=5, P>0.05). In the study group (n=5), the ERP was shortened following subendocardial ischemia. ERP dispersion decreased significantly from 48+/-9 ms to 36+/-13 ms 30 min after the ischemia (P=0.02). There was neither spontaneous nor stimulation-induced ventricular arrhythmia after ischemia.
CONCLUSION: Acute subendocardial ischemia leads to a homogenous reduction of ventricular ERP. This may partially explain why subendocardial ischemia is associated with a low incidence of ventricular arrhythmia.
Keywords: Sheep; Subendocardial ischemia; Ventricular refractory period
References
- J Am Coll Cardiol. 1989 Dec;14(7):1618-25 - PubMed
- Clin Exp Pharmacol Physiol. 1996 Feb;23(2):111-8 - PubMed
- Am Heart J. 1989 Jan;117(1):151-9 - PubMed
- Am J Cardiol. 1977 Mar;39(3):407-12 - PubMed
- Circulation. 1977 Aug;56(2):217-24 - PubMed
- Circ Res. 1971 Jan;28(1):3-15 - PubMed
- J Am Coll Cardiol. 1990 Jul;16(1):49-54 - PubMed
- Am J Cardiol. 1987 Dec 1;60(16):1246-53 - PubMed
- Cardiovasc Res. 1974 Sep;8(5):647-55 - PubMed
- Circulation. 1986 Dec;74(6):1266-79 - PubMed
- Am Heart J. 1950 Feb;39(2):273-8 - PubMed
- J Cardiovasc Pharmacol. 1990 Apr;15(4):633-43 - PubMed
- Circ Res. 1966 Jan;18(1):18-25 - PubMed
- Am J Cardiol. 1990 Feb 15;65(7):412-6 - PubMed
- Circulation. 1975 Jun;51(6):1003-14 - PubMed
- Am J Cardiol. 1983 Jan 1;51(1):61-4 - PubMed
- Circulation. 1975 Apr;51(4):656-67 - PubMed
- Circulation. 1988 Dec;78(6):1365-72 - PubMed
- Cardiovasc Res. 2003 Sep 1;59(3):705-14 - PubMed
- Am J Cardiol. 1992 May 1;69(14):1243-4 - PubMed
- J Mol Cell Cardiol. 1984 Mar;16(3):247-59 - PubMed
- Circulation. 1983 Jun;67(6):1356-67 - PubMed
- J Electrocardiol. 1971;4(1):34-43 - PubMed
- Circulation. 1950 Jun;1(6):1318-28 - PubMed
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