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Deeb SS, Brunzell JD. The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy. PPAR Res. 2009;2009:649286doi: 10.1155/2009/649286.
Deeb, S. S., & Brunzell, J. D. (2009). The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy. PPAR research, 2009649286. https://doi.org/10.1155/2009/649286
Deeb, Samir S, and Brunzell, John D. "The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy." PPAR research vol. 2009 (2009): 649286. doi: https://doi.org/10.1155/2009/649286
Deeb SS, Brunzell JD. The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy. PPAR Res. 2009;2009:649286. doi: 10.1155/2009/649286. Epub 2009 Apr 07. PMID: 19360113; PMCID: PMC2666270.
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PPAR Res. 2009;2009:649286. doi: 10.1155/2009/649286. Epub 2009 Apr 07.

The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy.

PPAR research

Samir S Deeb, John D Brunzell

Affiliations

  1. Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195-7720, USA. [email protected]

PMID: 19360113 PMCID: PMC2666270 DOI: 10.1155/2009/649286

Abstract

The Diabetes Control and Complications Trial (DCCT) involved intensive diabetes therapy of subjects with type 1 diabetes mellitus (T1DM) for an average period of 6.5 years. A subset of these subjects gained excessive weight. We tested for association of polymorphisms in 8 candidate genes with the above trait. We found the Gly482Ser polymorphism in the peroxisome proliferator-activated receptor γ coactivator-1α (PGC1α) to be significantly associated with weight gain in males (P = .0045) but not in females. The Ser allele was associated with greater weight gain than the Gly allele (P = .005). Subjects with a family history of type 2 diabetes mellitus (T2DM) were more common among those who gained excessive weight. We conclude that T2DM and the Gly482Ser polymorphism in PGC1α contribute to the effect of intensive diabetes therapy on weight gain in males with T1DM.

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