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Elshafie O, Grant C, Al-Hamdani A, et al. VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. Sultan Qaboos Univ Med J. 2011;11(1):104-7
Elshafie, O., Grant, C., Al-Hamdani, A., Jain, R., & Woodhouse, N. (2011). VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. Sultan Qaboos University medical journal, 11(1), 104-7.
Elshafie, Omayma, et al. "VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide." Sultan Qaboos University medical journal vol. 11,1 (2011): 104-7.
Elshafie O, Grant C, Al-Hamdani A, Jain R, Woodhouse N. VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide. Sultan Qaboos Univ Med J. 2011 Feb;11(1):104-7. Epub 2011 Feb 12. PMID: 21509215; PMCID: PMC3074686.
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Sultan Qaboos Univ Med J. 2011 Feb;11(1):104-7. Epub 2011 Feb 12.

VIPoma Crisis: Immediate and life saving reduction of massive stool volumes on starting treatment with octreotide.

Sultan Qaboos University medical journal

Omayma Elshafie, Christopher Grant, Aisha Al-Hamdani, Rajeev Jain, Nicholas Woodhouse

Affiliations

  1. Departments of Medicine and.

PMID: 21509215 PMCID: PMC3074686

Abstract

We report the case of a 57-year-old male physician who presented with a life threatening secretory and refractory diarrhoea of around 20 L/day. This was complicated by severe hypotension, hypokalaemia, hypercalcaemia, renal failure requiring dialysis, metabolic acidosis, cardiorespiratory arrest and ventilation for 12 days. His diarrhoea responded immediately to the first dose of a therapeutic trial of subcutaneous octreotide 100 mcg 8 hourly which was started on clinical grounds alone before any investigations were carried out. After one day he was extubated and his blood pressure returned to normal. When a functioning neuroendocrine tumour is suspected clinically, the use of octreotide can, as in this case, be life saving.

Keywords: Cardiopulmonary arrest; Case report; Chromogranin A; Diarrhoea; Neuroendocrine tumour; Octreotide; Oman; Pancreatic tumour; VIPoma

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