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Paredes SD, Barriga C, Reiter RJ, et al. Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model. Int J Tryptophan Res. 2009;2:23-36doi: 10.4137/ijtr.s1129.
Paredes, S. D., Barriga, C., Reiter, R. J., & Rodríguez, A. B. (2009). Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model. International journal of tryptophan research : IJTR, 223-36. https://doi.org/10.4137/ijtr.s1129
Paredes, Sergio D, et al. "Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model." International journal of tryptophan research : IJTR vol. 2 (2009): 23-36. doi: https://doi.org/10.4137/ijtr.s1129
Paredes SD, Barriga C, Reiter RJ, Rodríguez AB. Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model. Int J Tryptophan Res. 2009;2:23-36. doi: 10.4137/ijtr.s1129. Epub 2009 Jan 14. PMID: 22084580; PMCID: PMC3195230.
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Int J Tryptophan Res. 2009;2:23-36. doi: 10.4137/ijtr.s1129. Epub 2009 Jan 14.

Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model.

International journal of tryptophan research : IJTR

Sergio D Paredes, Carmen Barriga, Russel J Reiter, Ana B Rodríguez

Affiliations

  1. Department of Physiology (Neuroimmunophysiology Research Group), Faculty of Science, University of Extremadura, Badajoz, Spain.

PMID: 22084580 PMCID: PMC3195230 DOI: 10.4137/ijtr.s1129

Abstract

In the present review we summarize the relationship between the amino acid, tryptophan, the neurotransmitter, serotonin, and the indole, melatonin, with the rhythms of sleep/wake and the immune response along with the possible connections between the alterations in these rhythms due to aging and the so-called "serotonin and melatonin deficiency state." The decrease associated with aging of the brain and circulating levels of serotonin and melatonin seemingly contributes to the alterations of both the sleep/wake cycle and the immune response that typically accompany old age. The supplemental administration of tryptophan, e.g. the inclusion of tryptophan-enriched food in the diet, might help to remediate these age-related alterations due to its capacity of raise the serotonin and melatonin levels in the brain and blood. Herein, we also summarize a set of studies related to the potential role that tryptophan, and its derived product melatonin, may play in the restoration of the aged circadian rhythms of sleep/wake and immune response, taking the ringdove (Streptopeliarisoria) as a suitable model.

Keywords: immune function; melatonin; ringdove; serotonin; sleep-wake cycle; tryptophan

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