Display options
Cite
Khosravi S, Alavian SM, Zare A, et al. Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings. Hepat Mon. 2011;11(6):452-8
Khosravi, S., Alavian, S. M., Zare, A., Daryani, N. E., Fereshtehnejad, S. M., Daryani, N. E., Keramati, M. R., Abdollahzade, S., & Taba Taba Vakili, S. (2011). Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings. Hepatitis monthly, 11(6), 452-8.
Khosravi, Somaye, et al. "Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings." Hepatitis monthly vol. 11,6 (2011): 452-8.
Khosravi S, Alavian SM, Zare A, Daryani NE, Fereshtehnejad SM, Daryani NE, Keramati MR, Abdollahzade S, Taba Taba Vakili S. Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings. Hepat Mon. 2011 Jun;11(6):452-8. PMID: 22087177; PMCID: PMC3212791.
Copy Download .nbib Format: NLM
Share it on

Hepat Mon. 2011 Jun;11(6):452-8.

Non-alcoholic fatty liver disease and correlation of serum alanin aminotransferase level with histopathologic findings.

Hepatitis monthly

Somaye Khosravi, Seyed Moayed Alavian, Ali Zare, Nasser Ebrahimi Daryani, Seyed-Mohammad Fereshtehnejad, Narges Ebrahimi Daryani, Mohammad Reza Keramati, Sina Abdollahzade, Sahar Taba Taba Vakili

Affiliations

  1. Department of Gastroenterology, Tehran University of Medical Sciences, Tehran, IR Iran.

PMID: 22087177 PMCID: PMC3212791

Abstract

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) has been recognized as the most common cause of chronic liver disease worldwide. It occurs in patients who do not consume alcohol in large amounts. Alanine aminotranferase (ALT) and aspartate aminotransferase (AST) are indicators of hepatocellular injury.

OBJECTIVES: To determine correlation between histopathologic specifications of NAFLD in patients with little or no history of alcohol consumption and the serum level of ALT.

PATIENTS AND METHODS: In a cross-sectional study carried out in two gastroenterology and hepatology clinics in Tehran, Iran, the medical records of those who had undergone liver biopsies between years 2005 and 2009 were reviewed. Clinical and laboratory information of biopsy-proven cases of NAFLD were obtained from 147 eligible medical records. The histopathologic, demographic, and laboratory data of the participants were also collected. Two groups of patients according to their serum ALT level (cut-point of 35 U/L) were defined. The quantitative pathologic grade of the biopsy specimens was determined based on Brunt scoring system.

RESULTS: We studied 147 NAFLD patients including 127 men (86.4%) and 20 women (13.6%) with a mean ± SD age of 41.4 ± 11.2 years. Considering serum ALT, the mean ± SD quantitative grade of hepatosteatosis was 1.50 ± 0.67 and 1.74 ± 0.73 (p=0.136); advanced fibrosis (consisted of grade III and cirrhosis) was found in 4.5% (1/22) and 5.6% (7/125) of patients (p=0.327).

CONCLUSIONS: We found that using the cut-off value of 35 U/L for serum ALT level, it has little contribution to predict NAFLD severity.

Keywords: Histopathology; Non-alcoholic fatty liver disease; Serum alanine aminotranferase

References

  1. Am J Med. 1993 Oct;95(4):447-9 - PubMed
  2. Hepatology. 1999 Dec;30(6):1356-62 - PubMed
  3. Ann Intern Med. 2002 Jul 2;137(1):1-10 - PubMed
  4. Aliment Pharmacol Ther. 2004 Jul 1;20(1):45-9 - PubMed
  5. Hepatology. 2005 Sep;42(3):650-6 - PubMed
  6. Hepatology. 2004 Dec;40(6):1387-95 - PubMed
  7. Gastroenterology. 1999 Jun;116(6):1413-9 - PubMed
  8. Hepatology. 2005 Feb;41(2):380-2 - PubMed
  9. Jpn J Med. 1988 May;27(2):142-9 - PubMed
  10. J Clin Endocrinol Metab. 2005 Mar;90(3):1578-82 - PubMed
  11. J Hepatol. 2005 Sep;43(3):508-14 - PubMed
  12. Hepatology. 2003 Apr;37(4):917-23 - PubMed
  13. Gastroenterology. 2002 Jul;123(1):134-40 - PubMed
  14. Hepatology. 2005 Jul;42(1):44-52 - PubMed
  15. Clin Chem. 1978 Nov;24(11):1971-9 - PubMed
  16. Hepatology. 1999 Mar;29(3):664-9 - PubMed
  17. J Hepatol. 2007 Aug;47(2):239-44 - PubMed
  18. Ann Intern Med. 2008 Mar 4;148(5):348-52 - PubMed
  19. Hepatology. 2008 Sep;48(3):792-8 - PubMed
  20. Am J Gastroenterol. 1999 Sep;94(9):2467-74 - PubMed
  21. Gastroenterology. 2003 Jan;124(1):71-9 - PubMed
  22. Gastroenterology. 2005 Jul;129(1):113-21 - PubMed
  23. Hepatology. 2003 Jun;37(6):1286-92 - PubMed
  24. Hepatology. 2007 Apr;45(4):846-54 - PubMed
  25. Hepatology. 2006 Apr;43(4):682-9 - PubMed
  26. Aliment Pharmacol Ther. 2009 Feb 15;29(4):387-96 - PubMed
  27. Ann Hepatol. 2006 Jan-Mar;5(1):30-3 - PubMed

Publication Types