Indian J Pediatr. 2012 Sep;79(9):1228-9. doi: 10.1007/s12098-011-0675-7. Epub 2012 Jan 14.

Perinatal tuberculosis associated hemophagocytic lymphohistiocytosis.

Indian journal of pediatrics

Prabhat Maheshwari, Rajiv Chhabra, Padam Yadav

PMID: 22246612 DOI: 10.1007/s12098-011-0675-7

Abstract

Hemophagocytic lymphohistiocytosis [HLH] is a reactive disorder characterized by generalised non-malignant histiocytic proliferation with prominent hemophagocytosis. It may be either primary [familial (FLH)] or secondary [infection or malignancy associated]. Organisms incriminated for infection associated hemophagocytic syndrome (IAHS) include viruses, bacteria, spirochetes, fungi and parasites. Reports of IAHS associated with tuberculosis in neonates are rare. The authors report a case of perinatal tuberculosis presenting as hemophagocytic lymphohistiocytosis.

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MeSH terms

• Female
• Humans
• Infant, Newborn
• Lymphohistiocytosis, Hemophagocytic / diagnosis
• Lymphohistiocytosis, Hemophagocytic / drug therapy
• Lymphohistiocytosis, Hemophagocytic / etiology*
• Prognosis
• Tuberculosis / complications*
• Tuberculosis / diagnosis

Publication Types

• Case Reports
• Journal Article