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Beccano-Kelly D, Harvey J. Leptin: a novel therapeutic target in Alzheimer's disease?. Int J Alzheimers Dis. 2012;2012:594137doi: 10.1155/2012/594137.
Beccano-Kelly, D., & Harvey, J. (2012). Leptin: a novel therapeutic target in Alzheimer's disease?. International journal of Alzheimer's disease, 2012594137. https://doi.org/10.1155/2012/594137
Beccano-Kelly, Dayne, and Harvey, Jenni. "Leptin: a novel therapeutic target in Alzheimer's disease?." International journal of Alzheimer's disease vol. 2012 (2012): 594137. doi: https://doi.org/10.1155/2012/594137
Beccano-Kelly D, Harvey J. Leptin: a novel therapeutic target in Alzheimer's disease?. Int J Alzheimers Dis. 2012;2012:594137. doi: 10.1155/2012/594137. Epub 2012 Jan 02. PMID: 22254146; PMCID: PMC3255100.
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Int J Alzheimers Dis. 2012;2012:594137. doi: 10.1155/2012/594137. Epub 2012 Jan 02.

Leptin: a novel therapeutic target in Alzheimer's disease?.

International journal of Alzheimer's disease

Dayne Beccano-Kelly, Jenni Harvey

Affiliations

  1. Division of Neuroscience, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK.

PMID: 22254146 PMCID: PMC3255100 DOI: 10.1155/2012/594137

Abstract

It is well established that the hormone leptin circulates in the plasma in amounts proportional to body fat content and it regulates food intake and body weight via its actions in the hypothalamus. However, numerous studies have shown that leptin receptors are widely expressed throughout the CNS and evidence is growing that leptin plays a role in modulating a variety of neuronal processes. In particular, recent studies have highlighted a potential cognitive enhancing role for leptin as it regulates diverse aspects of hippocampal synaptic function that are thought to underlie learning and memory processes including glutamate receptor trafficking, dendritic morphology, and activity-dependent synaptic plasticity. Characterisation of the novel actions of leptin in limbic brain regions is providing valuable insights into leptin's role in higher cognitive functions in health and disease.

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