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Loeppky JA, Risling R. Ventilatory response to high inspired carbon dioxide concentrations in anesthetized dogs. N Am J Med Sci. 2011;3(2):63-9doi: 10.4297/najms.2011.363.
Loeppky, J. A., & Risling, R. (2011). Ventilatory response to high inspired carbon dioxide concentrations in anesthetized dogs. North American journal of medical sciences, 3(2), 63-9. https://doi.org/10.4297/najms.2011.363
Loeppky, Jack A, and Risling, Ray. "Ventilatory response to high inspired carbon dioxide concentrations in anesthetized dogs." North American journal of medical sciences vol. 3,2 (2011): 63-9. doi: https://doi.org/10.4297/najms.2011.363
Loeppky JA, Risling R. Ventilatory response to high inspired carbon dioxide concentrations in anesthetized dogs. N Am J Med Sci. 2011 Feb;3(2):63-9. doi: 10.4297/najms.2011.363. PMID: 22540067; PMCID: PMC3336888.
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N Am J Med Sci. 2011 Feb;3(2):63-9. doi: 10.4297/najms.2011.363.

Ventilatory response to high inspired carbon dioxide concentrations in anesthetized dogs.

North American journal of medical sciences

Jack A Loeppky, Ray Risling

Affiliations

  1. 2725 7th Street South, Cranbrook, British Columbia, V1C 4R8, Canada.

PMID: 22540067 PMCID: PMC3336888 DOI: 10.4297/najms.2011.363

Abstract

BACKGROUND: The ventilation ( ) response to inspired CO(2) has been extensively studied, but rarely with concentrations >10%.

AIMS: These experiments were performed to determine whether would increase correspondingly to higher concentrations and according to conventional chemoreceptor time delays.

MATERIALS AND METHODS: We exposed anesthetized dogs acutely, with and without vagotomy and electrical stimulation of the right vagus, to 20-100% CO(2)-balance O(2) and to 0 and 10% O(2)-balance N(2).

RESULTS: The time delays decreased and response magnitude increased with increasing concentrations (p<0.01), but at higher concentrations the time delays were shorter than expected, i.e., 0.5 s to double at 100% CO(2), with the response to 0% O(2) being ~3 s slower. Right vagotomy significantly reduced baseline breathing frequency (fR), increased tidal volume (VT) and increased the time delay by ~3 s. Bilateral vagotomy further reduced baseline fR and , and reduced the response to CO(2) and increased the time delay by ~12 s. Electro-stimulation of the peripheral right vagus while inspiring CO(2) caused a 13 s asystole and further reduced and delayed the response, especially after bilateral vagotomy, shifting the mode from VT to fR.

CONCLUSIONS: Results indicate that airway or lung receptors responded to the rapid increase in lung H(+) and that vagal afferents and unimpaired circulation seem necessary for the initial rapid response to high CO(2) concentrations by receptors upstream from the aortic bodies.

Keywords: Central chemoreceptors; lung chemoreceptors; nociceptors; peripheral chemoreceptors; vagotomy

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