Display options
Share it on

Sultan Qaboos Univ Med J. 2011 May;11(2):259-64. Epub 2011 May 15.

Myelomatous Pleural Effusion: Case report and review of the literature.

Sultan Qaboos University medical journal

Khalil Al-Farsi, Ibrahim Al-Haddabi, Nafla Al-Riyami, Rashid Al-Sukaiti, Salam Al-Kindi

Affiliations

  1. Departments of Haematology.

PMID: 21969899 PMCID: PMC3121032

Abstract

Plasma cell myeloma is an uncommon disease which, besides primarily involving the bone marrow, has a tendency to involve other organs thus presenting with different clinical manifestations. While pleural effusions are infrequent in this disease, true myelomatous pleural effusions are extremely rare. We report the case of a middle-aged Omani man with relapsed plasma cell myeloma who developed bilateral pleural effusions. The diagnosis of myelomatous pleural effusion was made by finding many abnormal plasma cells as well as a high level of a monoclonal protein (IgG κ) in the pleural fluid. In spite of a good initial response to therapy, the patient had progressive disease and died 6 months later with bacterial sepsis. We present a review of the literature that indicates the rarity of such a manifestation and its association with poor prognosis and short survival.

Keywords: Case report; Multiple myeloma; Oman; Plasma cells; Pleural effusion

References

  1. Intern Med. 2008;47(21):1917-20 - PubMed
  2. Mayo Clin Proc. 2003 Jan;78(1):21-33 - PubMed
  3. Diagn Cytopathol. 2000 Mar;22(3):147-51 - PubMed
  4. Br J Haematol. 2003 Jun;121(5):749-57 - PubMed
  5. Indian J Cancer. 2010 Jul-Sep;47(3):351-2 - PubMed
  6. Haematologica. 1988 Jul-Aug;73(4):325-6 - PubMed
  7. Leuk Res. 2005 Jun;29(6):715-8 - PubMed
  8. Arch Intern Med. 1978 May;138(5):727-30 - PubMed
  9. Acta Haematol. 2008;120(2):108-11 - PubMed
  10. Chest. 1994 Feb;105(2):622-4 - PubMed
  11. Cancer. 2008 Apr 1;112(7):1529-37 - PubMed
  12. Br J Haematol. 2007 Nov;139(4):621-2 - PubMed
  13. Indian J Chest Dis Allied Sci. 2010 Jan-Mar;52(1):47-9 - PubMed
  14. Br J Haematol. 1995 Jul;90(3):619-24 - PubMed
  15. Chest. 2004 Apr;125(4):1546-55 - PubMed
  16. QJM. 2010 Sep;103(9):705-6 - PubMed
  17. South Med J. 1997 Jan;90(1):65-8 - PubMed
  18. Cytojournal. 2007 Sep 07;4:17 - PubMed
  19. Leuk Res. 2009 Apr;33(4):577-8 - PubMed
  20. Cancer. 1979 Sep;44(3):1150-4 - PubMed
  21. Leuk Lymphoma. 2005 Aug;46(8):1137-42 - PubMed
  22. Oncology. 1977;34(1):20-4 - PubMed
  23. Chest. 1992 Jul;102(1):296-7 - PubMed
  24. Intern Med. 1992 May;31(5):617-21 - PubMed

Publication Types