J Pain Res. 2012;5:77-87. doi: 10.2147/JPR.S21965. Epub 2012 Apr 23.
Controlled release formulation of oxycodone in patients with moderate to severe chronic osteoarthritis: a critical review of the literature.
Journal of pain research
Robert Taylor, Robert B Raffa, Joseph V Pergolizzi
PMID: 22570559
PMCID: PMC3346069 DOI: 10.2147/JPR.S21965
Abstract
Osteoarthritis (OA) is a physically and emotionally debilitating disease that predominantly affects the aging adult population. Current pharmacologic treatment options primarily consist of nonsteroidal anti-inflammatory drugs and/or acetaminophen, but associated side effects, analgesic limitations, especially in the elderly, and the need for around-the-clock analgesia have led physicians to search for alternative analgesics. Opioids have shown effectiveness at mitigating both chronic cancer and noncancer pain, and their ability to be placed into controlled release (CR) formulations suggests that they may prove efficacious for OA patients. One formulation, oxycodone CR, has shown effectiveness in cancer pain patients and in some trials of noncancer low back pain. In this review, the objective was to synthesize the reported findings by researchers in this field and present an up-to-date look at the efficacy, safety, and tolerability of oxycodone CR in OA patients. Public literature databases were searched using specific keywords (eg, oxycodone CR) for studies assessing the efficacy and safety profile of oxycodone CR and its use in patients with OA. A total of eleven articles that matched the criteria were identified, which included three placebo-controlled trials, six comparative trials, one pharmacokinetic study in the elderly, and one long-term safety trial. Analysis of the studies revealed that oxycodone CR is reasonably efficacious, safe, and tolerable when used to manage moderate to severe chronic OA pain, with similar side effects to that of other opioids.
Keywords: controlled release; extended release; opioid; osteoarthritis; oxycodone
References
- CMAJ. 2006 May 23;174(11):1589-94 - PubMed
- Am J Ther. 2008 May-Jun;15(3):241-55 - PubMed
- Arch Intern Med. 2003 Jan 27;163(2):169-78 - PubMed
- Clin Drug Investig. 2010;30(8):489-505 - PubMed
- Adv Ther. 2010 Jun;27(6):381-99 - PubMed
- Am J Ther. 2000 Mar;7(2):75-90 - PubMed
- Br J Anaesth. 2012 Mar;108(3):491-8 - PubMed
- Drugs. 2003;63(1):17-32 - PubMed
- Pain. 1992 Apr;49(1):87-91 - PubMed
- Arthritis Rheum. 2008 Jan;58(1):26-35 - PubMed
- Arthritis Rheum. 2000 Sep;43(9):1905-15 - PubMed
- Pain. 1997 Oct;73(1):37-45 - PubMed
- Clin Ther. 2007 May;29(5):874-888 - PubMed
- Arthritis Res Ther. 2009;11(3):227 - PubMed
- J Clin Oncol. 1998 Oct;16(10):3222-9 - PubMed
- BMJ. 2004 Dec 4;329(7478):1317 - PubMed
- Clin J Pain. 2005 Nov-Dec;21(6):524-35 - PubMed
- Clin Geriatr Med. 2010 Aug;26(3):387-99 - PubMed
- Arch Intern Med. 2000 Mar 27;160(6):853-60 - PubMed
- Osteoarthritis Cartilage. 2007 Sep;15(9):981-1000 - PubMed
- Pain Pract. 2010 Sep-Oct;10(5):416-27 - PubMed
- Cochrane Database Syst Rev. 2006 Jan 25;(1):CD004257 - PubMed
- Curr Med Res Opin. 2006 Aug;22(8):1503-14 - PubMed
- J Gen Intern Med. 2007 Apr;22(4):485-90 - PubMed
- Jpn J Clin Oncol. 2004 Oct;34(10):608-14 - PubMed
- Expert Opin Drug Deliv. 2006 Jul;3(4):489-97 - PubMed
- J Pain. 2009 Feb;10(2):113-30 - PubMed
- Curr Rheumatol Rep. 2006 Feb;8(1):22-9 - PubMed
- Aging Clin Exp Res. 2003 Oct;15(5):359-63 - PubMed
- Am J Ther. 2001 May-Jun;8(3):181-6 - PubMed
- Rheumatology (Oxford). 2004 Feb;43 Suppl 1:i4-8 - PubMed
- J Fam Pract. 2011 Apr;60(4):206-12 - PubMed
- Clin Geriatr Med. 2010 Aug;26(3):355-69 - PubMed
- Curr Opin Rheumatol. 2002 Jan;14(1):63-71 - PubMed
- Hosp Pract (1995). 2011 Feb;39(1):62-73 - PubMed
- Clin Med Res. 2007 Mar;5(1):19-34 - PubMed
- J Clin Pharmacol. 2001 May;41(5):500-6 - PubMed
- Curr Opin Rheumatol. 2011 Sep;23(5):492-6 - PubMed
- Am J Epidemiol. 1995 Mar 15;141(6):539-45 - PubMed
- Patient. 2008 Jul 1;1(3):223-38 - PubMed
- Pain Pract. 2008 Jul-Aug;8(4):287-313 - PubMed
- Ann Rheum Dis. 2004 Aug;63(8):901-7 - PubMed
- Z Rheumatol. 1999 Jun;58(3):142-7 - PubMed
- Pain Med. 2009 Sep;10(6):1062-83 - PubMed
- BMJ. 2002 Sep 21;325(7365):624 - PubMed
- Am J Kidney Dis. 1996 Jul;28(1 Suppl 1):S3-6 - PubMed
- Osteoarthritis Cartilage. 2008 Apr;16(4):415-22 - PubMed
- Eur J Pain. 1998;2(3):239-49 - PubMed
- Pain Med. 2005 Sep-Oct;6(5):357-66 - PubMed
- Ann Intern Med. 2007 Oct 2;147(7):492-504 - PubMed
- J Rheumatol. 1999 Apr;26(4):862-9 - PubMed
- Pain Pract. 2011 May-Jun;11(3):230-9 - PubMed
- Am Fam Physician. 2000 Mar 15;61(6):1795-804 - PubMed
- Pain Med. 2011 May;12(5):755-60 - PubMed
Publication Types