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Ouzounis CA. Rise and demise of bioinformatics? Promise and progress. PLoS Comput Biol. 2012;8(4):e1002487doi: 10.1371/journal.pcbi.1002487.
Ouzounis, C. A. (2012). Rise and demise of bioinformatics? Promise and progress. PLoS computational biology, 8(4), e1002487. https://doi.org/10.1371/journal.pcbi.1002487
Ouzounis, Christos A. "Rise and demise of bioinformatics? Promise and progress." PLoS computational biology vol. 8,4 (2012): e1002487. doi: https://doi.org/10.1371/journal.pcbi.1002487
Ouzounis CA. Rise and demise of bioinformatics? Promise and progress. PLoS Comput Biol. 2012;8(4):e1002487. doi: 10.1371/journal.pcbi.1002487. Epub 2012 Apr 26. PMID: 22570600; PMCID: PMC3343106.
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PLoS Comput Biol. 2012;8(4):e1002487. doi: 10.1371/journal.pcbi.1002487. Epub 2012 Apr 26.

Rise and demise of bioinformatics? Promise and progress.

PLoS computational biology

Christos A Ouzounis

Affiliations

  1. Institute of Agrobiotechnology, Centre for Research & Technology Hellas-CERTH, Thessaloniki, Greece. [email protected]

PMID: 22570600 PMCID: PMC3343106 DOI: 10.1371/journal.pcbi.1002487

Abstract

The field of bioinformatics and computational biology has gone through a number of transformations during the past 15 years, establishing itself as a key component of new biology. This spectacular growth has been challenged by a number of disruptive changes in science and technology. Despite the apparent fatigue of the linguistic use of the term itself, bioinformatics has grown perhaps to a point beyond recognition. We explore both historical aspects and future trends and argue that as the field expands, key questions remain unanswered and acquire new meaning while at the same time the range of applications is widening to cover an ever increasing number of biological disciplines. These trends appear to be pointing to a redefinition of certain objectives, milestones, and possibly the field itself.

References

  1. Genome Med. 2009 Jan 20;1(1):2 - PubMed
  2. Proc AMIA Symp. 1998;:53-61 - PubMed
  3. Bull Math Biol. 2007 Feb;69(2):635-57 - PubMed
  4. Biochem Mol Biol Educ. 2005 Mar;33(2):82-5 - PubMed
  5. Annu Rev Plant Biol. 2006;57:335-60 - PubMed
  6. Brief Bioinform. 2003 Jun;4(2):105-23 - PubMed
  7. Trends Biotechnol. 2001 May;19(5):159-60 - PubMed
  8. Curr Opin Chem Biol. 2008 Feb;12(1):72-7 - PubMed
  9. Brief Bioinform. 2009 Jul;10(4):354-66 - PubMed
  10. Bioinformatics. 2010 Feb 15;26(4):445-55 - PubMed
  11. Evol Bioinform Online. 2007 Feb 17;2:121-8 - PubMed
  12. Nat Rev Drug Discov. 2006 Jan;5(1):23-6 - PubMed
  13. Trends Genet. 2008 Mar;24(3):142-9 - PubMed
  14. Bioinformatics. 2000 Aug;16(8):663-4 - PubMed
  15. Science. 2000 Oct 20;290(5491):471-3 - PubMed
  16. Mol Syst Biol. 2007;3:158 - PubMed
  17. Bioinformatics. 2007 Jul 15;23(14):1713-7 - PubMed
  18. Arch Microbiol. 2010 Mar;192(3):151-5 - PubMed
  19. Bioinformatics. 2002 Mar;18(3):377-8 - PubMed
  20. Nat Rev Microbiol. 2008 Dec;6(12):948-54 - PubMed
  21. Genet Mol Res. 2004 Dec 30;3(4):564-74 - PubMed
  22. Bioinformatics. 2000 Mar;16(3):187-9 - PubMed
  23. Nat Genet. 2003 Mar;33 Suppl:305-10 - PubMed
  24. PLoS Comput Biol. 2005 Nov;1(6):e52 - PubMed
  25. Nat Genet. 2007 Jul;39(7 Suppl):S7-15 - PubMed
  26. Comp Funct Genomics. 2002;3(4):380-6 - PubMed
  27. Front Physiol. 2010 May 07;1:3 - PubMed
  28. Curr Mol Med. 2007 Feb;7(1):133-41 - PubMed
  29. Science. 1998 May 29;280(5368):1327 - PubMed
  30. Philos Trans R Soc Lond B Biol Sci. 2006 Mar 29;361(1467):525-7 - PubMed
  31. Bioinformatics. 2003 Nov 22;19(17):2176-90 - PubMed
  32. J Comput Biol. 1996 Fall;3(3):465-78 - PubMed
  33. Annu Rev Biophys Biomol Struct. 2002;31:423-41 - PubMed
  34. Nat Rev Genet. 2008 Sep;9(9):678-88 - PubMed
  35. Trends Biotechnol. 2004 Nov;22(11):564-9 - PubMed
  36. J R Soc Interface. 2009 Aug 6;6 Suppl 4:S477-91 - PubMed
  37. Nat Rev Mol Cell Biol. 2003 Feb;4(2):157-62 - PubMed
  38. Bioinformatics. 2006 Jan 15;22(2):127-8 - PubMed
  39. J Biomed Inform. 2006 Jun;39(3):314-20 - PubMed
  40. Science. 2001 Feb 16;291(5507):1260-1 - PubMed
  41. PLoS Comput Biol. 2009 Oct;5(10):e1000481 - PubMed
  42. J Am Med Inform Assoc. 2011 Jul-Aug;18(4):354-7 - PubMed
  43. Nature. 2008 Sep 4;455(7209):47-50 - PubMed
  44. Brief Bioinform. 2010 Nov;11(6):544-51 - PubMed
  45. Nature. 2004 Apr 15;428(6984):774-7 - PubMed
  46. Neurosurg Focus. 2005 Oct 15;19(4):E2 - PubMed
  47. Pharmacogenomics. 2004 Sep;5(6):721-30 - PubMed
  48. Expert Opin Ther Targets. 2008 Apr;12(4):383-9 - PubMed
  49. Nat Biotechnol. 2000 Nov;18(11):1147-50 - PubMed
  50. Brief Bioinform. 2007 Mar;8(2):88-95 - PubMed
  51. Nat Rev Genet. 2009 Jan;10(1):9-18 - PubMed
  52. Trends Biotechnol. 2001 Sep;19(9):334-9 - PubMed
  53. Methods Inf Med. 2004;43(3):208-14 - PubMed
  54. Brief Bioinform. 2010 Jan;11(1):80-95 - PubMed
  55. Genome Biol. 2008;9 Suppl 2:S8 - PubMed
  56. Per Med. 2011 Jan;8(1):1-4 - PubMed
  57. Bioinformatics. 2011 Jul 1;27(13):1741-8 - PubMed
  58. Proteins. 2010 Jan;78(1):95-108 - PubMed
  59. Exp Gerontol. 2003 Oct;38(10):1031-6 - PubMed
  60. J Am Med Inform Assoc. 2008 Nov-Dec;15(6):709-14 - PubMed
  61. Nat Biotechnol. 2009 Jul;27(7):627-32 - PubMed
  62. Nat Rev Genet. 2010 May;11(5):367-79 - PubMed
  63. Bioinformatics. 2002 Apr;18(4):505-6 - PubMed

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