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Eriksson JG, Gelow J, Thornburg KL, et al. Long-term effects of placental growth on overweight and body composition. Int J Pediatr. 2012;2012:324185doi: 10.1155/2012/324185.
Eriksson, J. G., Gelow, J., Thornburg, K. L., Osmond, C., Laakso, M., Uusitupa, M., Lindi, V., Kajantie, E., & Barker, D. J. (2012). Long-term effects of placental growth on overweight and body composition. International journal of pediatrics, 2012324185. https://doi.org/10.1155/2012/324185
Eriksson, Johan G, et al. "Long-term effects of placental growth on overweight and body composition." International journal of pediatrics vol. 2012 (2012): 324185. doi: https://doi.org/10.1155/2012/324185
Eriksson JG, Gelow J, Thornburg KL, Osmond C, Laakso M, Uusitupa M, Lindi V, Kajantie E, Barker DJ. Long-term effects of placental growth on overweight and body composition. Int J Pediatr. 2012;2012:324185. doi: 10.1155/2012/324185. Epub 2012 Apr 18. PMID: 22570665; PMCID: PMC3337610.
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Int J Pediatr. 2012;2012:324185. doi: 10.1155/2012/324185. Epub 2012 Apr 18.

Long-term effects of placental growth on overweight and body composition.

International journal of pediatrics

Johan G Eriksson, Jill Gelow, Kent L Thornburg, Clive Osmond, Markku Laakso, Matti Uusitupa, Virpi Lindi, Eero Kajantie, David J P Barker

Affiliations

  1. Department of General Practice and Primary Health Care, University of Helsinki, PL 20, 00014 Helsinki, Finland.

PMID: 22570665 PMCID: PMC3337610 DOI: 10.1155/2012/324185

Abstract

Obesity is programmed in utero and small babies generally have small placentas. In some circumstances, an undernourished fetus can expand its placental surface to extract more nutrients. We hypothesize that this results in an imbalanced nutrient supply to the fetus leading to obesity. To determine whether placental size determines overweight and body composition, we studied 2003 subjects in adult life. Associations between placental surface area and indices of overweight were restricted to people who carried the Pro12Pro genotype of the PPARĪ³2 gene. For every 1 SD increase in placental surface area, the odds ratio for overweight was 1.37 (95% CI 1.10 to 1.71; P = 0.005). Expansion of the placental surface in compensation for fetal undernutrition increases the risk of overweight and a higher body fat percentage in people carrying the Pro12Pro genotype. We suggest that similar underlying multifactorial mechanisms affect the development of obesity in general.

References

  1. N Engl J Med. 2008 May 8;358(19):1991-2002 - PubMed
  2. Int J Dev Biol. 2010;54(2-3):525-30 - PubMed
  3. Int J Obes (Lond). 2007 Sep;31(9):1392-9 - PubMed
  4. Am J Hum Biol. 2010 Jul-Aug;22(4):508-11 - PubMed
  5. Vasc Health Risk Manag. 2008;4(2):297-304 - PubMed
  6. Diabetes. 2002 Jul;51(7):2321-4 - PubMed
  7. Am J Clin Nutr. 2004 Jul;80(1):199-203 - PubMed
  8. Br J Nutr. 1991 Mar;65(2):157-68 - PubMed
  9. Curr Diabetes Rev. 2007 Feb;3(1):33-9 - PubMed
  10. Diabetologia. 2006 Dec;49(12):2853-8 - PubMed
  11. Int J Dev Biol. 2010;54(2-3):469-73 - PubMed
  12. BMJ. 2001 Apr 21;322(7292):949-53 - PubMed
  13. Endocrinology. 2010 Oct;151(10):4969-81 - PubMed
  14. Expert Opin Ther Targets. 2007 Nov;11(11):1503-20 - PubMed
  15. Annu Rev Biochem. 2008;77:289-312 - PubMed
  16. BMJ. 1991 Oct 26;303(6809):1019-22 - PubMed
  17. Am J Clin Nutr. 1999 Nov;70(5):811-6 - PubMed
  18. Semin Fetal Neonatal Med. 2009 Apr;14(2):119-24 - PubMed
  19. N Engl J Med. 2005 Oct 27;353(17):1802-9 - PubMed
  20. J Reprod Immunol. 2011 Jun;90(1):41-9 - PubMed
  21. Am J Physiol Endocrinol Metab. 2000 Jul;279(1):E83-7 - PubMed
  22. Int J Epidemiol. 2001 Feb;30(1):15-23 - PubMed
  23. Am J Hum Biol. 2010 Jul-Aug;22(4):512-6 - PubMed
  24. Nature. 2004 Jul 22;430(6998):419-21 - PubMed
  25. Am J Epidemiol. 2007 Nov 15;166(10):1126-33 - PubMed

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