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Thomas BC, Jacobi C, Korporal M, et al. Ocular outcome and frequency of neurological manifestations in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). J Ophthalmic Inflamm Infect. 2012;2(3):125-31doi: 10.1007/s12348-012-0077-7.
Thomas, B. C., Jacobi, C., Korporal, M., Becker, M. D., Wildemann, B., & Mackensen, F. (2012). Ocular outcome and frequency of neurological manifestations in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). Journal of ophthalmic inflammation and infection, 2(3), 125-31. https://doi.org/10.1007/s12348-012-0077-7
Thomas, Bettina C, et al. "Ocular outcome and frequency of neurological manifestations in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE)." Journal of ophthalmic inflammation and infection vol. 2,3 (2012): 125-31. doi: https://doi.org/10.1007/s12348-012-0077-7
Thomas BC, Jacobi C, Korporal M, Becker MD, Wildemann B, Mackensen F. Ocular outcome and frequency of neurological manifestations in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE). J Ophthalmic Inflamm Infect. 2012 Sep;2(3):125-31. doi: 10.1007/s12348-012-0077-7. Epub 2012 May 11. PMID: 22573398; PMCID: PMC3438297.
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J Ophthalmic Inflamm Infect. 2012 Sep;2(3):125-31. doi: 10.1007/s12348-012-0077-7. Epub 2012 May 11.

Ocular outcome and frequency of neurological manifestations in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE).

Journal of ophthalmic inflammation and infection

Bettina C Thomas, Christian Jacobi, Mirjam Korporal, Matthias D Becker, Brigitte Wildemann, Friederike Mackensen

Affiliations

  1. Interdisciplinary Uveitis Centre, Department of Ophthalmology, University of Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Germany, [email protected].

PMID: 22573398 PMCID: PMC3438297 DOI: 10.1007/s12348-012-0077-7

Abstract

PURPOSE: The purpose of this study was to describe the visual prognosis as well as the frequency and clinical severity of central nervous system involvement in all acute posterior multifocal placoid pigment epitheliopathy (APMPPE) patients of one centre.

METHODS: A retrospective database review of all patients and a prospective clinical, ophthalmological and neurological follow-up, if possible, were conducted.

RESULTS: Eighteen patients with APMPPE were included with a mean follow-up of 17.1 months. Thirteen patients participated in a follow-up exam. Visual acuity improved in 9 of 18 patients to a mean of 0.17 log minimum angle of resolution (MAR) in the worse eye and remained stable in eight patients (mean, 0.03 logMAR). In the majority of patients, the 30° static perimetry improved at follow-up compared to the initial exams. Still, in up to 50 to 60 %, small visual field defects persisted. Overall, 11 patients (61 %) showed neurologic symptoms of varying severity. The most common neurological symptom was headache in nine (50 %) patients. Other symptoms included paraesthesias, psychosis, vertigo, and, as the most severe complication, stroke due to cerebral vasculitis. Fifteen patients were treated with systemic corticosteroids.

CONCLUSIONS: Visual prognosis is good in patients with APMPPE, but visual field defects may remain. Neurological signs and symptoms, especially headaches, are frequent in APMPPE and should be taken seriously. Adequate investigations including MRI and CSF examination should be initiated in these patients.

References

  1. J Neuroophthalmol. 2009 Jun;29(2):111-8 - PubMed
  2. Am J Ophthalmol. 1972 Dec;74(6):1066-74 - PubMed
  3. Cephalalgia. 2009 Jun;29(6):694-8 - PubMed
  4. Cerebrovasc Dis. 2004;18(4):338-9 - PubMed
  5. Arch Ophthalmol. 2006 Jun;124(6):910-3 - PubMed
  6. Ophthalmology. 2001 May;108(5):861-8 - PubMed
  7. Am J Ophthalmol. 1977 Jul;84(1):45-9 - PubMed
  8. Ger J Ophthalmol. 1993 May;2(3):150-4 - PubMed
  9. Arch Ophthalmol. 1988 Jun;106(6):796-800 - PubMed
  10. Br J Ophthalmol. 1989 Dec;73(12):985-90 - PubMed
  11. Br J Ophthalmol. 1972 Dec;56(12):863-74 - PubMed
  12. Stroke. 1996 May;27(5):996-1001 - PubMed
  13. Arch Ophthalmol. 1973 May;89(5):373-6 - PubMed
  14. Arch Ophthalmol. 1968 Aug;80(2):177-85 - PubMed
  15. Case Rep Med. 2009;2009:481512 - PubMed
  16. AJNR Am J Neuroradiol. 2006 Jan;27(1):67-9 - PubMed
  17. Retina. 2009 Jul-Aug;29(7):994-1001 - PubMed
  18. Am J Ophthalmol. 1973 Oct;76(4):511-8 - PubMed
  19. Arch Ophthalmol. 1991 Jun;109(6):800-3 - PubMed
  20. Ann Ophthalmol. 1977 Jan;9(1):36-6 - PubMed
  21. Klin Monbl Augenheilkd. 2001 Dec;218(12):756-62 - PubMed
  22. Bull Soc Belge Ophtalmol. 1993;248:73-6 - PubMed
  23. Ocul Immunol Inflamm. 2007 Nov-Dec;15(6):443-6 - PubMed
  24. J Neurol. 1993 Nov;241(1):22-6 - PubMed

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