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Oduola T, Bello I, Idowu T, et al. Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya. N Am J Med Sci. 2010;2(5):234-7doi: 10.4297/najms.2010.2234.
Oduola, T., Bello, I., Idowu, T., Avwioro, G., Adeosun, G., & Olatubosun, L. (2010). Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya. North American journal of medical sciences, 2(5), 234-7. https://doi.org/10.4297/najms.2010.2234
Oduola, Taofeeq, et al. "Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya." North American journal of medical sciences vol. 2,5 (2010): 234-7. doi: https://doi.org/10.4297/najms.2010.2234
Oduola T, Bello I, Idowu T, Avwioro G, Adeosun G, Olatubosun L. Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya. N Am J Med Sci. 2010 May;2(5):234-7. doi: 10.4297/najms.2010.2234. PMID: 22574295; PMCID: PMC3347650.
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N Am J Med Sci. 2010 May;2(5):234-7. doi: 10.4297/najms.2010.2234.

Histopathological changes in Wistar albino rats exposed to aqueous extract of unripe Carica papaya.

North American journal of medical sciences

Taofeeq Oduola, Ibrahim Bello, Thomas Idowu, Godwin Avwioro, Ganiyu Adeosun, Luqman Olatubosun

Affiliations

  1. Department of Haematology, Special Investigations Laboratory, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.

PMID: 22574295 PMCID: PMC3347650 DOI: 10.4297/najms.2010.2234

Abstract

BACKGROUND: Exposure of animals to xenobiotics may or may not trigger adverse response at cellular levels. Aqueous extract of unripe Carica papaya is consumed by sickle cell patients as antisickling agent in Western Nigeria.

AIM: This study was undertaken to investigate the effects of Carica papaya on certain organs in Wister albino rats exposed to aqueous extract of unripe Carica papaya.

MATERIALS AND METHODS: Different doses of aqueous extract of unripe Carica papaya were administered orally daily for 42 days to six groups of rats. At the end of exposure, the animals were sacrificed and tissue sections were prepared from livers, kidneys, hearts and small intestines using standard techniques.

RESULTS: Histopathological results showed that no pathological changes were observed in tissue sections of experimental animals when compared with tissue sections of the same organs in control animals.

CONCLUSION: No pathological changes were elicited in the organs of rats exposed to aqueous extract of unripe Carica papaya.

Keywords: Carica papaya; exposure; histopathological changes; organs

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