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RSC Adv. 2012 Jan 01;2(17):6765-6767. doi: 10.1039/C2RA20853A. Epub 2012 Jul 12.

Electromodulated Release of Nitric Oxide Through Polymer Material from Reservoir of Inorganic Nitrite Salt.

RSC advances

Lajos Höfler, Dipankar Koley, Jianfeng Wu, Chuanwu Xi, Mark E Meyerhoff

Affiliations

  1. Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.

PMID: 22888401 PMCID: PMC3414219 DOI: 10.1039/C2RA20853A

Abstract

Herein, we report a new approach to electromodulate the release of NO at physiological levels through polymeric materials from a stable nitrite electrolyte reservoir, with potential application in controlling biofilm formation and clotting on intravascular catheters. The NO flux can be turned 'on' and 'off' electrochemically, on demand.

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