Display options
Cite
Beiraghdar M, Pourmoghaddas Z, Reza Torknezhad M, et al. Ejection fraction and mortality rate of patients with isolated acute inferior myocardial infarction reperfused by streptokinase. ARYA Atheroscler. 2011;7(2):54-7
Beiraghdar, M., Pourmoghaddas, Z., Reza Torknezhad, M., & Torkan, A. (2011). Ejection fraction and mortality rate of patients with isolated acute inferior myocardial infarction reperfused by streptokinase. ARYA atherosclerosis, 7(2), 54-7.
Beiraghdar, Mozhdeh, et al. "Ejection fraction and mortality rate of patients with isolated acute inferior myocardial infarction reperfused by streptokinase." ARYA atherosclerosis vol. 7,2 (2011): 54-7.
Beiraghdar M, Pourmoghaddas Z, Reza Torknezhad M, Torkan A. Ejection fraction and mortality rate of patients with isolated acute inferior myocardial infarction reperfused by streptokinase. ARYA Atheroscler. 2011;7(2):54-7. PMID: 22577446; PMCID: PMC3347851.
Copy Download .nbib Format: NLM
Share it on

ARYA Atheroscler. 2011;7(2):54-7.

Ejection fraction and mortality rate of patients with isolated acute inferior myocardial infarction reperfused by streptokinase.

ARYA atherosclerosis

Mozhdeh Beiraghdar, Zahra Pourmoghaddas, Mohammad Reza Torknezhad, Ali Torkan

Affiliations

  1. MD, Assistant Researcher, Department of Cardiology, Najaf Abad Branch, Islamic Azad University, Isfahan, Iran.

PMID: 22577446 PMCID: PMC3347851

Abstract

BACKGROUND: This study aimed to evaluate the effects of streptokinase on left ventricular ejection fraction and mortality rate of patients with inferior acute myocardial infarction (AMI) without right ventricular myocardial infarction (RVMI).

METHODS: Fifty five consecutive patients with the diagnosis of inferior AMI without RVMI in the coronary care unit (CCU) of Shariati Hospital in Isfahan were selected for this study. Patients who had a history and/or electrocardiogram (ECG) evidence of previous myocardial infarction, evidence of bundle branch block, historical or clinical findings of valvular or other non-coronary heart diseases or heart failure were excluded. Participants were divided into two groups. Group one (n=28) had no contraindication for taking thrombolytic therapy and group two (n=27) had at least one contraindication for this treatment. Patients in group one took 1,000,000 units streptokinase for one hour. Three days later, LVEF of all participants was measured by an experienced cardiologist using 2-dimentiona1 echocardiography. Patients were followed up until four weeks to assess the mortality rate.

RESULTS: One death in the first 24 hours was reported in group one. However, no death was reported in any group until four weeks after discharge. There was no significant difference in mortality rate during the first 24 hours and four weeks after discharge between the two groups. Mean LVEF in the two groups did not show any significant difference (P=0.21).

CONCLUSION: Probably streptokinase has no effects on one-month mortality rate and LVEF in patients with inferior AMI without RVMI. Therefore, streptokinase side effects must be taken into consideration when being administered for this group of patients.

Keywords: Inferior Acute Myocardial Infarction; Left Ventricular Ejection Fraction; Mortality Rate; Streptokinase

References

  1. Lancet. 1989 Jun 17;1(8651):1367-9 - PubMed
  2. J Am Coll Cardiol. 1988 Dec;12(6 Suppl A):3A-13A - PubMed
  3. Angiology. 1999 Aug;50(8):619-28 - PubMed
  4. Heart. 1997 Jun;77(6):506-11 - PubMed
  5. Lancet. 1994 Feb 5;343(8893):311-22 - PubMed
  6. Circulation. 1983 Mar;67(3):558-65 - PubMed
  7. J Am Coll Cardiol. 1990 Jul;16(1):223-31 - PubMed
  8. Am J Cardiol. 1988 Sep 1;62(7):347-51 - PubMed
  9. Am Heart J. 1989 Jul;118(1):138-44 - PubMed
  10. Br Heart J. 1995 Feb;73(2):108-9 - PubMed
  11. J Am Coll Cardiol. 1994 Aug;24(2):362-9 - PubMed

Publication Types