ARYA Atheroscler. 2011;7(3):111-7.
Acute and chronic effects of morphine on cardiovascular system and the baroreflexes sensitivity during severe increase in blood pressure in rats.
ARYA atherosclerosis
Ali Asghar Pour Shanazari, Zahra Aslani, Efat Ramshini, Hojatolah Alaei
Affiliations
Affiliations
- Associate Professor, Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
PMID: 22577457
PMCID: PMC3347855
Abstract
BACKGROUND: This study aimed to determine the role and effects of baroreflexes during acute increase in blood pressure (BP) after severe and long-term infusion of morphine.
METHODS: This experimental study was conducted on male desert rats. They were assigned into 4 groups and the rats of the case group received morphine in the short and long term periods, whereas the control rats received normal saline for the same duration. Then, the rats were anesthetized, and their femoral artery and vein were cannulated for the injection of phenylephrine and naloxone, respectively. The injection of phenylephrine was performed by the device after a period of recording BP, mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity (BRS) in order to induce acute hypertension before and after injecting naloxone. The Student t-test and analysis of variance (ANOVA) were used for statistical analysis.
RESULTS: The obtained results suggested that acute and chronic injections of morphine may cause significant reduction in systolic and diastolic arterial BP as well as the mean arterial pressure; moreover, it significantly increased the sensitivity of baroreflexes. Furthermore, the increased baroreflex sensitivity was observed after acute injection of morphine, whereas chronic morphine injection caused reduction in baroreflex sensitivity.
CONCLUSION: It seems that the details of the opiates' effects on the body including cardiovascular system depend on the type of opioids and consequently, on the type of stimulated receptor.
Keywords: Baroreflex Sensitivity; Blood Pressure; Morphine
References
- J Clin Psychiatry. 1989 Nov;50(11):403-12 - PubMed
- Arq Bras Cardiol. 2009 Mar;92(3):205-15 - PubMed
- Arch Dis Child Fetal Neonatal Ed. 2006 Jan;91(1):F46-51 - PubMed
- Hypertension. 1997 Jan;29(1 Pt 1):105-10 - PubMed
- Brain Res. 1993 May 28;612(1-2):70-7 - PubMed
- Ann N Y Acad Sci. 1982;398:434-47 - PubMed
- J Am Coll Cardiol. 1994 Jan;23(1):194-200 - PubMed
- J Stud Alcohol. 1987 Jul;48(4):356-70 - PubMed
- Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):491-6 - PubMed
- Clin Exp Pharmacol Physiol. 2002 Mar;29(3):238-42 - PubMed
- Am J Physiol Regul Integr Comp Physiol. 2004 Oct;287(4):R715-28 - PubMed
- Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91 - PubMed
- Brain Res. 2006 Feb 16;1073-1074:365-73 - PubMed
- Eur J Pharmacol. 2007 Dec 8;576(1-3):107-13 - PubMed
- J Auton Nerv Syst. 1988 Dec;25(2-3):165-72 - PubMed
- Trends Pharmacol Sci. 1996 Jul;17(7):264-9 - PubMed
- Acta Physiol Scand. 1988 Dec;134(4):479-91 - PubMed
- Brain Res. 2000 Jan 3;852(1):76-83 - PubMed
- Life Sci. 1988;42(11):1117-22 - PubMed
- Br J Addict. 1989 Feb;84(2):227-8 - PubMed
- J Am Vet Med Assoc. 2007 Jun 1;230(11):1665-8 - PubMed
- J Biomed Sci. 2000 May-Jun;7(3):213-20 - PubMed
- Anesth Analg. 2004 Jun;98(6):1698-1704 - PubMed
- Clin Sci (Lond). 1988 Jul;75(1):71-7 - PubMed
- J Cardiovasc Pharmacol. 1992;20(5):688-93 - PubMed
- Naunyn Schmiedebergs Arch Pharmacol. 1982 Jun;319(3):206-11 - PubMed
- Circulation. 1989 Oct;80(4):1010-5 - PubMed
- Br J Pharmacol. 1989 Jul;97(3):873-81 - PubMed
Publication Types